Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Mondillo, Carolina | - |
| dc.creator | Falus, Andras | - |
| dc.creator | Pignataro, Omar Pedro | - |
| dc.creator | Pap, Erna | - |
| dc.date | 2017-10-09T20:56:09Z | - |
| dc.date | 2017-10-09T20:56:09Z | - |
| dc.date | 2007-01 | - |
| dc.date | 2017-10-06T18:01:53Z | - |
| dc.date.accessioned | 2019-04-29T15:44:08Z | - |
| dc.date.available | 2019-04-29T15:44:08Z | - |
| dc.date.issued | 2017-10-09T20:56:09Z | - |
| dc.date.issued | 2017-10-09T20:56:09Z | - |
| dc.date.issued | 2007-01 | - |
| dc.date.issued | 2017-10-06T18:01:53Z | - |
| dc.identifier | Mondillo, Carolina; Falus, Andras; Pignataro, Omar Pedro; Pap, Erna; Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects Leydig cell function; American Society of Andrology; Journal of Andrology; 28; 1; 1-2007; 86-91 | - |
| dc.identifier | 0196-3635 | - |
| dc.identifier | http://hdl.handle.net/11336/26291 | - |
| dc.identifier | 1939-4640 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300659 | - |
| dc.description | The present study focuses on histaminergic regulation of Leydig cell physiology, since limited information is available so far. To evaluate the dependency of Leydig cells on histamine (HA), we performed experiments using highly purified Leydig cells in culture, isolated from wild type (WT) and histidine decarboxylase (Hdc) gene knockout (HDC KO)-so HA-deprived-mice. HDC KO Leydig cells showed lower basal and human choriogonadotropin (hCG)-induced testosterone production compared to WT Leydig cells, presumably due to altered P450scc gene (Cyp11a1) expression levels. Moreover, in HDC KO cells, hCG did not increase basal expression levels of HA H1 and H2 receptor genes, while the hormone showed a significant inducing effect in WT cells. Based on these findings, we propose that prolonged HA deficiency in HDC KO mice affects various aspects of Leydig cell physiology, most importantly the response to hCG, providing definite evidence that HA plays a role as direct modulator of Leydig cell function and steroid synthesis in the testis. Also, the results presented herein constitute the first molecular evidence for the expression of HA H1 and H2 receptor subtypes in isolated Leydig cells. | - |
| dc.description | Fil: Mondillo, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Falus, Andras. Semmelweis Egyetem; Hungría | - |
| dc.description | Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina | - |
| dc.description | Fil: Pap, Erna. Semmelweis Egyetem; Hungría | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society of Andrology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.2164/jandrol.106.000257/abstract | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2164/jandrol.106.000257 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | HUMAN CHORIOGONADOTROPIN | - |
| dc.subject | STEROIDOGENESIS | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects Leydig cell function | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.