Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Toiber, Deborah | - |
| dc.creator | Erdel, Fabian | - |
| dc.creator | Bouazoune, Karim | - |
| dc.creator | Silberman, Dafne Magali | - |
| dc.creator | Zhong, Lei | - |
| dc.creator | Mulligan, Peter | - |
| dc.creator | Sebastián, Carlos | - |
| dc.creator | Cosentino, Claudia | - |
| dc.creator | Martínez Pastor, Bárbara | - |
| dc.creator | Giacosa, Sofia | - |
| dc.creator | D´Urso, Agustina | - |
| dc.creator | Näär, Anders M. | - |
| dc.creator | Kingston, Robert | - |
| dc.creator | Rippe, Karsten | - |
| dc.creator | Mostoslavsky, Raul | - |
| dc.date | 2016-11-24T19:03:54Z | - |
| dc.date | 2016-11-24T19:03:54Z | - |
| dc.date | 2013-08 | - |
| dc.date | 2016-11-24T17:20:25Z | - |
| dc.date.accessioned | 2019-04-29T15:44:11Z | - |
| dc.date.available | 2019-04-29T15:44:11Z | - |
| dc.date.issued | 2016-11-24T19:03:54Z | - |
| dc.date.issued | 2016-11-24T19:03:54Z | - |
| dc.date.issued | 2013-08 | - |
| dc.date.issued | 2016-11-24T17:20:25Z | - |
| dc.identifier | Toiber, Deborah; Erdel, Fabian; Bouazoune, Karim; Silberman, Dafne Magali; Zhong, Lei; et al.; SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling; Cell Press; Molecular Cell; 51; 4; 8-2013; 454-468 | - |
| dc.identifier | 1097-2765 | - |
| dc.identifier | http://hdl.handle.net/11336/8367 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300678 | - |
| dc.description | DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration, and aging. Little is known about the role of chromatin accessibility in DNA repair. Here, we find that the deacetylase sirtuin 6 (SIRT6) is one of the earliest factors recruited to double-strand breaks (DSBs). SIRT6 recruits the chromatin remodeler SNF2H to DSBs and focally deacetylates histone H3K56. Lack of SIRT6 and SNF2H impairs chromatin remodeling, increasing sensitivity to genotoxic damage and recruitment of downstream factors such as 53BP1 and breast cancer 1 (BRCA1). Remarkably, SIRT6-deficient mice exhibit lower levels of chromatin-associated SNF2H in specific tissues, a phenotype accompanied by DNA damage. We demonstrate that SIRT6 is critical for recruitment of a chromatin remodeler as an early step in the DNA damage response, indicating that proper unfolding of chromatin plays a rate-limiting role. We present a unique crosstalk between a histone modifier and a chromatin remodeler, regulating a coordinated response to prevent DNA damage. | - |
| dc.description | Fil: Toiber, Deborah. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Erdel, Fabian. Deutsches Krebsforschungszentrum; Alemania | - |
| dc.description | Fil: Bouazoune, Karim. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Silberman, Dafne Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Zhong, Lei. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Mulligan, Peter. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Sebastián, Carlos. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Cosentino, Claudia. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Martínez Pastor, Bárbara. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Giacosa, Sofia. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: D´Urso, Agustina. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Näär, Anders M.. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Kingston, Robert. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Rippe, Karsten. Harvard Medical School; Estados Unidos | - |
| dc.description | Fil: Mostoslavsky, Raul. Harvard Medical School; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Cell Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1097276513004759 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761390/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molcel.2013.06.018 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | SIRT6 | - |
| dc.subject | CROMATINA | - |
| dc.subject | EPIGENETICA | - |
| dc.subject | Otras Ciencias de la Salud | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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