Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | del Carmen, Silvina Andrea | - |
| dc.creator | Miyoshi, Anderson | - |
| dc.creator | Azevedo, Vasco | - |
| dc.creator | de Moreno, Maria Alejandra | - |
| dc.creator | Leblanc, Jean Guy Joseph | - |
| dc.date | 2017-11-17T14:29:40Z | - |
| dc.date | 2017-11-17T14:29:40Z | - |
| dc.date | 2015-02-20 | - |
| dc.date | 2017-07-03T20:44:25Z | - |
| dc.date.accessioned | 2019-04-29T15:44:12Z | - |
| dc.date.available | 2019-04-29T15:44:12Z | - |
| dc.date.issued | 2017-11-17T14:29:40Z | - |
| dc.date.issued | 2017-11-17T14:29:40Z | - |
| dc.date.issued | 2015-02-20 | - |
| dc.date.issued | 2017-07-03T20:44:25Z | - |
| dc.identifier | del Carmen, Silvina Andrea; Miyoshi, Anderson; Azevedo, Vasco; de Moreno, Maria Alejandra; Leblanc, Jean Guy Joseph; Evaluation of a Streptococcus thermophilus strain with innate anti-inflammatory properties as a vehicle for IL-10 cDNA delivery in an acute colitis model; Elsevier; Cytokine; 73; 2; 20-2-2015; 177-183 | - |
| dc.identifier | 1043-4666 | - |
| dc.identifier | http://hdl.handle.net/11336/28420 | - |
| dc.identifier | 1096-0023 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300682 | - |
| dc.description | The aim of this work was to develop a Streptococcus (S.) thermophilus strain with improved anti-inflammatory properties due to the incorporation of the therapeutic cDNA delivery plasmid pValac::il-10. To achieve this purpose, cells of S. thermophilus CRL807, previously selected as being an important anti-inflammatory strain, were electroporated with pValac::il-10 plasmid. In order to confirm the functionality of the developed strain, it was co-cultured with human epithelial cells Caco-2 and the production of IL-10 was evaluated by ELISA. Bacterial suspensions of S. thermophilus CRL807 containing pValac::il-10 plasmid or of the wild-type (WT) strain were administered in vivo using a murine model of intestinal inflammation. The animals treated with S. thermophilus CRL807 pValac::il-10 showed a lower body weight loss, microbial translocation to liver and damage scores in their intestines at macroscopical and microscopic levels. Furthermore, a significant increase was observed in the concentration of IL-10 in the intestinal contents of these mice compared to the rest of the experimental groups, accompanied by decreased levels of pro-inflammatory cytokines. The insertion of the therapeutic pValac::il-10 plasmid increased the intrinsic anti-inflammatory activity (synergetic effect) of S. thermophilus CRL807 which could be included in novel treatment protocols for inflammatory bowel diseases. | - |
| dc.description | Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina | - |
| dc.description | Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil | - |
| dc.description | Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil | - |
| dc.description | Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina | - |
| dc.description | Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cyto.2015.02.020 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1043466615000794 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | INFLAMMATORY BOWEL DISEASE | - |
| dc.subject | STREPTOCOCCUS THERMOPHILS | - |
| dc.subject | INTERLEUKIN-10 | - |
| dc.subject | DNA DELIVERY | - |
| dc.subject | ANTI INFLAMMATORY | - |
| dc.title | Evaluation of a Streptococcus thermophilus strain with innate anti-inflammatory properties as a vehicle for IL-10 cDNA delivery in an acute colitis model | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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