Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Grossebrummel, Hannah | - |
| dc.creator | Peter, Tilmann | - |
| dc.creator | Mandelkow, Robert | - |
| dc.creator | Weiss, Martin | - |
| dc.creator | Muzzio, Damián Oscar | - |
| dc.creator | Zimmermann, Uwe | - |
| dc.creator | Walther, Reinhard | - |
| dc.creator | Jensen, Cristian Federico | - |
| dc.creator | Knabbe, Cornelius | - |
| dc.creator | Zygmunt, Marek | - |
| dc.creator | Burchardt, Martin | - |
| dc.creator | Stope, Matthias B. | - |
| dc.date | 2017-06-13T18:26:44Z | - |
| dc.date | 2017-06-13T18:26:44Z | - |
| dc.date | 2015-11 | - |
| dc.date | 2017-06-07T20:28:45Z | - |
| dc.date.accessioned | 2019-04-29T15:44:17Z | - |
| dc.date.available | 2019-04-29T15:44:17Z | - |
| dc.date.issued | 2017-06-13T18:26:44Z | - |
| dc.date.issued | 2017-06-13T18:26:44Z | - |
| dc.date.issued | 2015-11 | - |
| dc.date.issued | 2017-06-07T20:28:45Z | - |
| dc.identifier | Grossebrummel, Hannah; Peter, Tilmann; Mandelkow, Robert; Weiss, Martin; Muzzio, Damián Oscar; et al.; Cytochrome P450 17A1 inhibitor abiraterone attenuates cellular growth of prostate cancer cells independently from androgen receptor signaling by modulation of oncogenic and apoptotic pathways; Spandidos Publ Ltd; International Journal Of Oncology; 48; 2; 11-2015 | - |
| dc.identifier | 1019-6439 | - |
| dc.identifier | http://hdl.handle.net/11336/18119 | - |
| dc.identifier | 1791-2423 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300724 | - |
| dc.description | Abiraterone provides significant survival advantages in prostate cancer (PC), however, the current understanding of the molecular mechanisms of abiraterone is still limited. Therefore, the abiraterone impact on androgen receptor (AR)-positive LNCaP and AR-negative PC-3 cells was assessed by cellular and molecular analyses. The present study demonstrated, that abiraterone treatment significantly decreased cell growth, AR expression, and AR activity of AR-positive LNCaP cells. Notably, AR-negative PC-3 cells exhibited comparable reductions in cellular proliferation, associated with DNA fragmentation and pro-apoptotic modulation of p21, caspase-3, survivin, and transforming growth factor β (TGFβ). Our observations suggest that the attenuation of AR signaling is not the only rationale to explain the abiraterone anticancer activity. Abiraterone efficacy may play a more global role in PC progression control than originally hypothesized. In this regard, abiraterone is not only a promising drug for treatment of AR-negative PC stages, even more, abiraterone may represent an alternative for treatment of other malignancies besides prostate cancer. | - |
| dc.description | Fil: Grossebrummel, Hannah. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Peter, Tilmann. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Mandelkow, Robert. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Weiss, Martin. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Muzzio, Damián Oscar. University Medicine Greifswald; Argentina | - |
| dc.description | Fil: Zimmermann, Uwe. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Walther, Reinhard. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Jensen, Cristian Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Knabbe, Cornelius. Ruhr-universität Bochum; Alemania | - |
| dc.description | Fil: Zygmunt, Marek. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Burchardt, Martin. University Medicine Greifswald; Alemania | - |
| dc.description | Fil: Stope, Matthias B.. University Medicine Greifswald; Alemania | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Spandidos Publ Ltd | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/ijo/48/2/793 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3892/ijo.2015.3274 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/18119 | - |
| dc.subject | Prostate cancer | - |
| dc.subject | Abiraterone | - |
| dc.subject | Cytochrome P450 17S1 | - |
| dc.subject | Apoptosis | - |
| dc.subject | Cell cycle | - |
| dc.subject | Transforming growth factor β | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Cytochrome P450 17A1 inhibitor abiraterone attenuates cellular growth of prostate cancer cells independently from androgen receptor signaling by modulation of oncogenic and apoptotic pathways | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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