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dc.provenanceCONICET-
dc.creatorRabinovich, Gabriel Adrián-
dc.creatorBaum, Linda Gwen-
dc.creatorTinari, N.-
dc.creatorPaganelli, Roberto-
dc.creatorNatoli, Clara-
dc.creatorLiu, Fu-tong-
dc.creatorIacobelli, Stéfano-
dc.date2017-12-14T22:26:10Z-
dc.date2017-12-14T22:26:10Z-
dc.date2002-12-
dc.date2017-12-04T17:54:13Z-
dc.date.accessioned2019-04-29T15:44:21Z-
dc.date.available2019-04-29T15:44:21Z-
dc.date.issued2017-12-14T22:26:10Z-
dc.date.issued2017-12-14T22:26:10Z-
dc.date.issued2002-12-
dc.date.issued2017-12-04T17:54:13Z-
dc.identifierRabinovich, Gabriel Adrián; Baum, Linda Gwen; Tinari, N.; Paganelli, Roberto; Natoli, Clara; et al.; Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?; Elsevier; Trends In Immunology; 23; 6; 12-2002; 313-320-
dc.identifier1471-4906-
dc.identifierhttp://hdl.handle.net/11336/30710-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300752-
dc.descriptionRecent evidence has implicated galectins and their ligands as master regulators of immune cell homeostasis. Whereas some members of this family, such as galectin-3, behave as amplifiers of the inflammatory cascade, others, such as galectin-1, trigger homeostatic signals to shut off T-cell effector functions. These carbohydrate-binding proteins, identified by shared consensus amino acid sequences and affinity for beta-galactoside-containing sugars, participate in the homeostasis of the inflammatory response, either by regulating cell survival and signaling, influencing cell growth and chemotaxis, interfering with cytokine secretion, mediating cell-cell and cell-matrix interactions or influencing tumor progression and metastasis. The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.-
dc.descriptionFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.descriptionFil: Baum, Linda Gwen. University of California at Los Angeles; Estados Unidos-
dc.descriptionFil: Tinari, N.. University ‘G. D; Italia-
dc.descriptionFil: Paganelli, Roberto. University ‘G. D; Italia-
dc.descriptionFil: Natoli, Clara. University ‘G. D; Italia-
dc.descriptionFil: Liu, Fu-tong. University of California at Davis; Estados Unidos-
dc.descriptionFil: Iacobelli, Stéfano. University ‘G. D; Italia-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.cell.com/trends/immunology/fulltext/S1471-4906(02)02232-9?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471490602022329%3Fshowall%3Dtrue-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/10.1016/S1471-4906(02)02232-9-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/12072371-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/30710-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleGalectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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