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dc.provenanceCONICET-
dc.creatorChicco, Adriana Graciela-
dc.creatorCreus, Agustina-
dc.creatorIllesca, Paola Guadalupe-
dc.creatorHein, Gustavo Juan-
dc.creatorRodriguez, Silvia-
dc.creatorFortino, María Alejandra-
dc.date2018-08-29T18:12:23Z-
dc.date2018-08-29T18:12:23Z-
dc.date2016-01-
dc.date2018-07-05T18:06:21Z-
dc.date.accessioned2019-04-29T15:44:21Z-
dc.date.available2019-04-29T15:44:21Z-
dc.date.issued2018-08-29T18:12:23Z-
dc.date.issued2018-08-29T18:12:23Z-
dc.date.issued2016-01-
dc.date.issued2018-07-05T18:06:21Z-
dc.identifierChicco, Adriana Graciela; Creus, Agustina; Illesca, Paola Guadalupe; Hein, Gustavo Juan; Rodriguez, Silvia; et al.; Effects of post-suckling n-3 polyunsaturated fatty acids: Prevention of dyslipidemia and liver steatosis induced in rats by a sucrose-rich diet during pre- and post-natal life; Royal Society of Chemistry; Food and Function; 7; 1; 1-2016; 445-454-
dc.identifier2042-6496-
dc.identifierhttp://hdl.handle.net/11336/57545-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300759-
dc.descriptionThe interaction between fetal programming and the post-natal environment suggests that the post-natal diet could amplify or attenuate programmed outcomes. We investigated whether dietary n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) at weaning resulted in an amelioration of dyslipidemia, adiposity and liver steatosis that was induced by a sucrose-rich diet (SRD; where the fat source is corn oil) from the onset of pregnancy up to adulthood. During pregnancy and lactation, dams were fed an SRD or the standard powdered rodent commercial diet (RD). At weaning and until 150 days of life, male offspring from SRD-dams were divided into two groups and fed an SRD or SRD-with-fish oil [where 6% of the corn oil was partially replaced by fish oil (FO) 5% and corn oil (CO) 1%], forming SRD-SRD or SRD-FO groups. Male offspring from RD-dams continued with RD up to the end of the experimental period, forming an RD-RD group. The presence of FO in the weaning diet showed the following: prevention of hypertriglyceridemia and liver steatosis, together with increased lipogenic enzyme activity caused by a maternal SRD; the complete normalization of CPT I activity and PPARα protein mass levels; a slight but not statistically significant accretion of visceral adiposity; and limited body fat content and reduced plasma free fatty acid levels. All of these results were observed even in the presence of a high-sucrose diet challenge after weaning. SRD-dams' breast milk showed a more saturated fatty acid composition. These results suggest the capacity of n-3 PUFAs to overcome some adverse outcomes induced by a maternal and post-weaning sucrose-rich diet.-
dc.descriptionFil: Chicco, Adriana Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina-
dc.descriptionFil: Creus, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina-
dc.descriptionFil: Illesca, Paola Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina-
dc.descriptionFil: Hein, Gustavo Juan. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina-
dc.descriptionFil: Rodriguez, Silvia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina-
dc.descriptionFil: Fortino, María Alejandra. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherRoyal Society of Chemistry-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1039/c5fo00705d-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2016/FO/C5FO00705D#!divAbstract-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/57545-
dc.subjectAFTER SUCKING DIET-
dc.subjectN-3 POLYUNSATURATED FATTY ACIDS-
dc.subjectPRE AND POST-NATAL SUCROSE-RICH DIET-
dc.subjectLIPID METABOLISM-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleEffects of post-suckling n-3 polyunsaturated fatty acids: Prevention of dyslipidemia and liver steatosis induced in rats by a sucrose-rich diet during pre- and post-natal life-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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