Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Cardama, Georgina Alexandra | - |
| dc.creator | González, Nazareno | - |
| dc.creator | Ciarlantini, Matias Sebastián | - |
| dc.creator | Gandolfi Donadío, Lucía | - |
| dc.creator | Comin, Maria Julieta | - |
| dc.creator | Alonso, Daniel Fernando | - |
| dc.creator | Lorenzano Menna, Pablo | - |
| dc.creator | Gomez, Daniel Eduardo | - |
| dc.date | 2018-02-07T19:22:07Z | - |
| dc.date | 2018-02-07T19:22:07Z | - |
| dc.date | 2014-07 | - |
| dc.date | 2018-02-07T17:29:59Z | - |
| dc.date.accessioned | 2019-04-29T15:44:29Z | - |
| dc.date.available | 2019-04-29T15:44:29Z | - |
| dc.date.issued | 2014-07 | - |
| dc.identifier | Cardama, Georgina Alexandra; González, Nazareno; Ciarlantini, Matias Sebastián; Gandolfi Donadío, Lucía; Comin, Maria Julieta; et al.; Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells; Dove Press; Oncotargets and Therapy; 2014; 7; 7-2014; 2021-2033 | - |
| dc.identifier | 1178-6930 | - |
| dc.identifier | http://hdl.handle.net/11336/36004 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/300809 | - |
| dc.description | Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity, plays a key role in the invasive phenotype of gliomas. Here we report the effect of ZINC69391, a specific Rac1 inhibitor developed by our group, on human glioma cell lines LN229 and U-87 MG. ZINC69391 is able to interfere with the interaction of Rac1 with Dock180, a relevant Rac1 activator in glioma invasion, and to reduce Rac1-GTP levels. The kinase Pak1, a downstream effector of Dock180–Rac1 signaling, was also downregulated upon ZINC69391 treatment. ZINC69391 reduced cell proliferation, arrested cells in G1 phase, and triggered apoptosis in glioma cells. Importantly, ZINC69391 dramatically affected cell migration and invasion in vitro, interfering with actin cytoskeleton dynamics. We also evaluated the effect of analog 1A-116, a compound derived from ZINC69391 structure. 1A-116 showed an improved antiproliferative and antiinvasive activity on glioma cells. These findings encourage further preclinical testing in clinically relevant animal models. | - |
| dc.description | Fil: Cardama, Georgina Alexandra. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: González, Nazareno. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Ciarlantini, Matias Sebastián. Instituto Nacional de Tecnología Industrial; Argentina | - |
| dc.description | Fil: Gandolfi Donadío, Lucía. Instituto Nacional de Tecnología Industrial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Comin, Maria Julieta. Instituto Nacional de Tecnología Industrial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Lorenzano Menna, Pablo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Gomez, Daniel Eduardo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Dove Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/proapoptotic-and-antiinvasive-activity-of-rac1-small-molecule-inhibito-peer-reviewed-article-OTT | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2147/OTT.S67998 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/36004 | - |
| dc.subject | Glioma | - |
| dc.subject | Rac1 | - |
| dc.subject | Invasion | - |
| dc.subject | Rho GTPases | - |
| dc.subject | Salud Ocupacional | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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