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dc.provenanceCONICET-
dc.creatorPerez Santangelo, Maria Soledad-
dc.creatorMancini, Estefania-
dc.creatorFrancey, Lauren J.-
dc.creatorSchlaen, Rubén Gustavo-
dc.creatorChernomoretz, Ariel-
dc.creatorHogenesch, John B.-
dc.creatorYanovsky, Marcelo Javier-
dc.date2016-12-06T21:19:34Z-
dc.date2016-12-06T21:19:34Z-
dc.date2014-10-
dc.date2016-11-25T16:34:34Z-
dc.date.accessioned2019-04-29T15:44:58Z-
dc.date.available2019-04-29T15:44:58Z-
dc.date.issued2014-10-
dc.identifierPerez Santangelo, Maria Soledad; Mancini, Estefania; Francey, Lauren J.; Schlaen, Rubén Gustavo; Chernomoretz, Ariel; et al.; Role for LSM genes in the regulation of circadian rhythms; National Academy Of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 111; 42; 10-2014; 15166-15171-
dc.identifier0027-8424-
dc.identifierhttp://hdl.handle.net/11336/8945-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301031-
dc.descriptionGrowing evidence suggests that core spliceosomal components differentially affect RNA processing of specific genes; however, whether changes in the levels or activities of these factors control specific signaling pathways is largely unknown. Here we show that some SM-like (LSM) genes, which encode core components of the spliceosomal U6 small nuclear ribonucleoprotein complex, regulate circadian rhythms in plants and mammals. We found that the circadian clock regulates the expression of LSM5 in Arabidopsis plants and several LSM genes in mouse suprachiasmatic nucleus. Further, mutations in LSM5 or LSM4 in Arabidopsis, or down-regulation of LSM3, LSM5, or LSM7 expression in human cells, lengthens the circadian period. Although we identified changes in the expression and alternative splicing of some core clock genes in Arabidopsis lsm5 mutants, the precise molecular mechanism causing period lengthening remains to be identified. Genome-wide expression analysis of either a weak lsm5 or a strong lsm4 mutant allele in Arabidopsis revealed larger effects on alternative splicing than on constitutive splicing. Remarkably, large splicing defects were not observed in most of the introns evaluated using RNA-seq in the strong lsm4 mutant allele used in this study. These findings support the idea that some LSM genes play both regulatory and constitutive roles in RNA processing, contributing to the fine-tuning of specific signaling pathways.-
dc.descriptionFil: Perez Santangelo, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina-
dc.descriptionFil: Mancini, Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina-
dc.descriptionFil: Francey, Lauren J.. University of Pennsylvania. Department of Systems Pharmacology and Translational Therapeutics; Estados Unidos-
dc.descriptionFil: Schlaen, Rubén Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina-
dc.descriptionFil: Chernomoretz, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina-
dc.descriptionFil: Hogenesch, John B.. University of Pennsylvania. Department of Systems Pharmacology and Translational Therapeutics; Estados Unidos-
dc.descriptionFil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina-
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dc.languageeng-
dc.publisherNational Academy Of Sciences-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/111/42/15166.long-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1073/pnas.1409791111-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/8945-
dc.subjectposttranscriptional-
dc.subjectalternative splicing-
dc.subjectcircadian clock-
dc.subjectArabidopsis-
dc.subjectmammals-
dc.subjectBioquímica y Biología Molecular-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleRole for LSM genes in the regulation of circadian rhythms-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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