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dc.provenanceCONICET-
dc.creatorBaier, Carlos Javier-
dc.creatorFranco, Diana Lorena-
dc.creatorGallegos, Cristina Eugenia-
dc.creatorMongiat, Lucas Alberto-
dc.creatorDionisio, Leonardo Raul-
dc.creatorBouzat, Cecilia Beatriz-
dc.creatorCaviedes, P.-
dc.creatorBarrantes, Francisco Jose-
dc.date2016-03-07T14:14:57Z-
dc.date2016-03-07T14:14:57Z-
dc.date2014-08-22-
dc.date2016-03-30 10:35:44.97925-03-
dc.date.accessioned2019-04-29T15:44:59Z-
dc.date.available2019-04-29T15:44:59Z-
dc.date.issued2014-08-22-
dc.identifierBaier, Carlos Javier; Franco, Diana Lorena; Gallegos, Cristina Eugenia; Mongiat, Lucas Alberto; Dionisio, Leonardo Raul; et al.; Corticosterone affects the differentiation of a neuronal cerebral cortex-derived cell line through modulation of the nicotinic acetylcholine receptor; Elsevier; Neuroscience; 274; 22-8-2014; 369-382-
dc.identifier0306-4522-
dc.identifierhttp://hdl.handle.net/11336/4647-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301038-
dc.descriptionChronic exposure to stress hormones has an impact on brain structures relevant to cognition. Nicotinic acetylcholine receptors (AChRs) are involved in numerous cognitive processes including learning and memory formation. In order to better understand the molecular mechanisms of chronic stress-triggered mental disease, the effect of corticosterone (CORT) on the biology of AChRs was studied in the neuronal cell line CNh. We found that chronic treatment with CORT reduced the expression levels of the α7-type neuronal AChR and, to a lesser extent, of α4-AChR. CORT also delayed the acquisition of the mature cell phenotype in CNh cells. Chronic nicotine treatment affected the differentiation of CNh cells and exerted a synergistic effect with CORT, suggesting that AChR could participate in signaling pathways that control the cell cycle. Overexpression of α7-AChR-GFP abolished the CORT effects on the cell cycle and the specific α7-AChR inhibitor, methyllycaconitine, mimicked the proliferative action exerted by CORT. Whole-cell voltage-clamp recordings showed a significant decrease in nicotine-evoked currents in CORT-treated cells. Taken together, these observations indicate that AChRs, and the α7-AChR in particular, could act as modulators of the differentiation of CNh cells and that CORT could impair the acquisition of a mature phenotype by affecting the function of this AChR subtype.-
dc.descriptionFil: Baier, Carlos Javier. Consejo Nacional de Investigaciones Cientí­ficas y Técnicas. Centro Científico Tecnológico Bahí­a Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Biomedicas; Argentina. Pontificia Universidad Católica Argentina "Santa Marí­a de los Buenos Aires"; Argentina-
dc.descriptionFil: Franco, Diana Lorena. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Biomedicas; Argentina. Pontificia Universidad Católica Argentina "Santa Marí­a de los Buenos Aires"; Argentina-
dc.descriptionFil: Gallegos, Cristina Eugenia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina-
dc.descriptionFil: Mongiat, Lucas Alberto. Fundación Instituto Leloir; Argentina-
dc.descriptionFil: Dionisio, Leonardo Raul. Consejo Nacional de Investigaciones Cientí­ficas y Técnicas. Centro Científico Tecnológico Bahí­a Blanca. Instituto de Investigaciones Bioquí­micas Bahí­a Blanca (i); Argentina-
dc.descriptionFil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina-
dc.descriptionFil: Caviedes, P.. Universidad de Chile; Chile-
dc.descriptionFil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa Marí­a de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0306452214004576-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuroscience.2014.05.049-
dc.relationinfo:eu-repo/semantics/altIdentifier/issn/0306-4522-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/4647-
dc.subjectCORTISCOSTERONE-
dc.subjectNICOTINIC ACETYLCHOLINE RECEPTOR-
dc.subjectNEUROSCIENCE-
dc.subjectNEURONAL CELL LINE-
dc.subjectBioquímica y Biología Molecular-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.subjectNeurociencias-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleCorticosterone affects the differentiation of a neuronal cerebral cortex-derived cell line through modulation of the nicotinic acetylcholine receptor-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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