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dc.provenanceCONICET-
dc.creatorDebes, Jose D.-
dc.creatorChan, Aaron J.-
dc.creatorBalderramo, Domingo-
dc.creatorKikuchi, Luciana-
dc.creatorGonzalez Ballerga, Esteban-
dc.creatorPrieto, Jhon E.-
dc.creatorTapias, Monica-
dc.creatorIdrovo, Victor-
dc.creatorDavalos, Milagros B.-
dc.creatorCairo, Fernando-
dc.creatorBarreyro, Fernando Javier-
dc.creatorParedes, Mario Sebastian-
dc.creatorHernandez, Nelia-
dc.creatorAvendaño, Karla-
dc.creatorDiaz Ferrer, Javier-
dc.creatorYang, Ju Dong-
dc.creatorCarrera, Enrique-
dc.creatorGarcia, Jairo A.-
dc.creatorMattos, Angelo Z.-
dc.creatorHirsch, Bruno S.-
dc.creatorGonçalves, Pablo T.-
dc.creatorCarrilho, Flair J.-
dc.creatorRoberts, Lewis R.-
dc.date2018-04-10T14:55:19Z-
dc.date2018-04-10T14:55:19Z-
dc.date2017-06-
dc.date2018-04-04T14:34:09Z-
dc.date.accessioned2019-04-29T15:45:27Z-
dc.date.available2019-04-29T15:45:27Z-
dc.date.issued2017-06-
dc.identifierDebes, Jose D.; Chan, Aaron J.; Balderramo, Domingo; Kikuchi, Luciana; Gonzalez Ballerga, Esteban; et al.; Hepatocellular carcinoma in South America: Evaluation of risk factors, demographics and therapy; Wiley Blackwell Publishing, Inc; Liver International; 38; 1; 6-2017; 136-143-
dc.identifier1478-3223-
dc.identifierhttp://hdl.handle.net/11336/41491-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301260-
dc.descriptionBackground & Aims: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Most studies addressing the epidemiology of HCC originate from developed countries. This study reports the preliminary findings of a multinational approach to characterize HCC in South America. Methods: We evaluated 1336 HCC patients seen at 14 centres in six South American countries using a retrospective study design with participating centres completing a template chart of patient characteristics. The diagnosis of HCC was made radiographically or histologically for all cases according to institutional standards. Methodology of surveillance for each centre was following AASLD or EASL recommendations. Results: Sixty-eight percent of individuals were male with a median age of 64 years at time of diagnosis. The most common risk factor for HCC was hepatitis C infection (HCV, 48%), followed by alcoholic cirrhosis (22%), Hepatitis B infection (HBV, 14%) and NAFLD (9%). We found that among individuals with HBV-related HCC, 38% were diagnosed before age 50. The most commonly provided therapy was transarterial chemoembolization (35% of HCCs) with few individuals being considered for liver transplant (<20%). Only 47% of HCCs were diagnosed during surveillance, and there was no difference in age of diagnosis between those diagnosed incidentally vs by surveillance. Nonetheless, being diagnosed during surveillance was associated with improved overall survival (P = .01). Conclusions: Our study represents the largest cohort to date reporting characteristics and outcomes of HCC across South America. We found an important number of HCCs diagnosed outside of surveillance programmes, with associated increased mortality in those patients.-
dc.descriptionFil: Debes, Jose D.. University of Minnesota; Estados Unidos-
dc.descriptionFil: Chan, Aaron J.. University of Minnesota; Estados Unidos-
dc.descriptionFil: Balderramo, Domingo. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina-
dc.descriptionFil: Kikuchi, Luciana. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Gonzalez Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina-
dc.descriptionFil: Prieto, Jhon E.. Organización Sanitas; Colombia. Centro de Enfermedades Hepáticas y Digestivas; Colombia-
dc.descriptionFil: Tapias, Monica. Organización Sanitas; Colombia. Fundación Santa Fe de Bogotá. Hospital Universitario; Colombia-
dc.descriptionFil: Idrovo, Victor. Organización Sanitas; Colombia. Fundación Santa Fe de Bogotá. Hospital Universitario; Colombia-
dc.descriptionFil: Davalos, Milagros B.. Hospital Nacional Edgardo Rebagliati Martins; Perú-
dc.descriptionFil: Cairo, Fernando. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina-
dc.descriptionFil: Barreyro, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina-
dc.descriptionFil: Paredes, Mario Sebastian. Provincia de Formosa. Ministerio de Salud. Hospital de Alta Complejidad "Pte. Juan Domingo Perón"; Argentina-
dc.descriptionFil: Hernandez, Nelia. Universidad de la República; Uruguay-
dc.descriptionFil: Avendaño, Karla. Universidad de la República; Uruguay-
dc.descriptionFil: Diaz Ferrer, Javier. Hospital Nacional Edgardo Rebagliati Martins; Perú-
dc.descriptionFil: Yang, Ju Dong. Mayo Clinic College of Medicine & Science; Estados Unidos-
dc.descriptionFil: Carrera, Enrique. Hospital Eugenio Espejo; Ecuador-
dc.descriptionFil: Garcia, Jairo A.. Fundación Valle del Lili; Colombia-
dc.descriptionFil: Mattos, Angelo Z.. Hospital Nossa Senhora da Conceição; Brasil-
dc.descriptionFil: Hirsch, Bruno S.. Hospital Nossa Senhora da Conceição; Brasil-
dc.descriptionFil: Gonçalves, Pablo T.. Hospital Nossa Senhora da Conceição; Brasil-
dc.descriptionFil: Carrilho, Flair J.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Roberts, Lewis R.. Mayo Clinic College of Medicine & Science; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherWiley Blackwell Publishing, Inc-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/liv.13502-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.13502-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/41491-
dc.subjectDEMOGRAPHICS-
dc.subjectHEPATOCELLULAR CARCINOMA-
dc.subjectRISK FACTORS-
dc.subjectSOUTH AMERICA-
dc.subjectMedicina Critica y de Emergencia-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleHepatocellular carcinoma in South America: Evaluation of risk factors, demographics and therapy-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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