Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Pastrana Rios, Belinda | - |
| dc.creator | Sosa, Liliana del Valle | - |
| dc.creator | Santiago, Jorge | - |
| dc.date | 2017-01-17T21:56:41Z | - |
| dc.date | 2017-01-17T21:56:41Z | - |
| dc.date | 2015-05 | - |
| dc.date | 2017-01-17T19:23:05Z | - |
| dc.date.accessioned | 2019-04-29T15:45:56Z | - |
| dc.date.available | 2019-04-29T15:45:56Z | - |
| dc.date.issued | 2015-05 | - |
| dc.identifier | Pastrana Rios, Belinda; Sosa, Liliana del Valle; Santiago, Jorge; Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complex; American Crystallographic Association; Structural Dynamics; 2; 4; 5-2015; 1-11 | - |
| dc.identifier | 2329-7778 | - |
| dc.identifier | http://hdl.handle.net/11336/11540 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301455 | - |
| dc.description | Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug design often involves the use of synthetic peptides which contain TFA (excipient). Our goal was to explore the effects of this excipient on a model complex: centrin-melittin-TFA. We performed Fourier transform infrared, two-dimensional infrared correlation spectroscopies and spectral simulations to analyze the amide I’/I’* band for the components and the ternary complex. Melittin (MLT) was observed to have increased helicity upon its interaction with centrin, followed by the thermally induced aggregation of MLT within the ternary complex in the TFA presence. | - |
| dc.description | Fil: Pastrana Rios, Belinda. Universidad de Puerto Rico; Puerto Rico | - |
| dc.description | Fil: Sosa, Liliana del Valle. Universidad de Puerto Rico; Puerto Rico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Santiago, Jorge. Universidad de Puerto Rico; Puerto Rico | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Crystallographic Association | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1063/1.4921219 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://aca.scitation.org/doi/10.1063/1.4921219 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Centrin | - |
| dc.subject | Melittin | - |
| dc.subject | Trifluoroacetic acid | - |
| dc.subject | Química Inorgánica y Nuclear | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complex | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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