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dc.creatorVera Candioti, Josefina-
dc.creatorSoloneski, Sonia Maria Elsa-
dc.creatorLarramendy, Marcelo Luis-
dc.date2017-12-22T21:16:47Z-
dc.date2017-12-22T21:16:47Z-
dc.date2013-05-
dc.date2017-12-21T16:27:16Z-
dc.date.accessioned2019-04-29T15:45:59Z-
dc.date.available2019-04-29T15:45:59Z-
dc.date.issued2013-05-
dc.identifierLarramendy, Marcelo Luis; Soloneski, Sonia Maria Elsa; Vera Candioti, Josefina; Chlorpyrifos-based insecticides induced genotoxic and cytotoxic effects in the ten spotted live-bearer fish, Cnesterodon decemmaculatus (Jenyns, 1842); Wiley; Environmental Toxicology; 29; 12; 5-2013; 1390-1398-
dc.identifier1520-4081-
dc.identifierhttp://hdl.handle.net/11336/31455-
dc.identifier1522-7278-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301473-
dc.descriptionMortality, genotoxicity, and cytotoxicity of the 48% chlorpyrifos (CPF)-based formulations Lorsban* 48E® and CPF Zamba® were evaluated on Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) under laboratory conditions. Induction of micronucleus (MN) and alterations in the erythrocyte/erythroblast frequencies were employed as end points for genotoxicity and cytotoxicity, respectively. For Lorsban* 48E®, mean values of 0.13 and 0.03 mg/L were determined for LC50 at 24 and 96 h, respectively, and these concentrations reached mean values of 0.40 and 0.21 mg/L for CPF Zamba®. Mortality values increased as a positive linear function of the CPF Zamba® concentrations, but not for Lorsban* 48E® concentrations. There was no significant relationship between mortality and exposure time within the 0–96 h period for both formulations. LC50 values indicated that the fish were seven fold more sensitive to Lorsban* 48E® than to CPF Zamba®. Lorsban* 48E® within the concentration range of 0.008–0.025 mg/L increased MN frequency at both 48 and 96 h of treatment. Similar results were also observed when fish were exposed to 0.052–0.155 mg/L of CPF Zamba®, regardless of the exposure time. Cellular cytotoxicity was found after Lorsban* 48E® and CPF Zamba® treatments for all concentrations and time exposures, estimated by a decrease in the frequency of mature erythrocytes and a concomitant enhanced frequency of erythroblasts in circulating blood. Furthermore, our results demonstrated that Lorsban* 48E® and CPF Zamba® should be considered as CPF-based commercial formulations with marked genotoxic and cytotoxic properties.-
dc.descriptionFil: Vera Candioti, Josefina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Soloneski, Sonia Maria Elsa. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Larramendy, Marcelo Luis. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
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dc.languageeng-
dc.publisherWiley-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/tox.21869-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/tox.21869/abstract-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectMORTALITY-
dc.subjectMICRONUCLEUS-
dc.subjectERYTHROCYTE:ERYTHROBLAST RATIO-
dc.subjectPOECILIIDAE-
dc.subjectLORSBAN* 48E®-
dc.subjectCHLORPYRIFOS ZAMBA®-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleChlorpyrifos-based insecticides induced genotoxic and cytotoxic effects in the ten spotted live-bearer fish, Cnesterodon decemmaculatus (Jenyns, 1842)-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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