Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Araya, Romina Elizabeth | - |
| dc.creator | Gomez Castro, Maria Florencia | - |
| dc.creator | Carasi, Paula | - |
| dc.creator | McCarville, Justin L. | - |
| dc.creator | Jury, Jennifer | - |
| dc.creator | Mowat, Allan M. | - |
| dc.creator | Verdu, Elena F. | - |
| dc.creator | Chirdo, Fernando Gabriel | - |
| dc.date | 2018-08-08T13:22:29Z | - |
| dc.date | 2018-08-08T13:22:29Z | - |
| dc.date | 2016-07 | - |
| dc.date | 2018-08-06T18:03:51Z | - |
| dc.date.accessioned | 2019-04-29T15:46:00Z | - |
| dc.date.available | 2019-04-29T15:46:00Z | - |
| dc.date.issued | 2016-07 | - |
| dc.identifier | Araya, Romina Elizabeth; Gomez Castro, Maria Florencia; Carasi, Paula; McCarville, Justin L.; Jury, Jennifer; et al.; Mechanisms of innate immune activation by gluten peptide p31-43 in mice; American Physiological Society; American Journal of Physiology-gastrointestinal and Liver Physiology; 311; 1; 7-2016; G40-G49 | - |
| dc.identifier | 0193-1857 | - |
| dc.identifier | http://hdl.handle.net/11336/54535 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301476 | - |
| dc.description | Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Innate immunity contributes to the pathogenesis of CD, but the mechanisms remain poorly understood. Although previous in vitro work suggests that gliadin peptide p31-43 acts as an innate immune trigger, the underlying pathways are unclear and have not been explored in vivo. Here we show that intraluminal delivery of p31-43 induces morphological changes in the small intestinal mucosa of normal mice consistent with those seen in CD, including increased cell death and expression of inflammatory mediators. The effects of p31-43 were dependent on MyD88 and type I IFNs, but not Toll-like receptor 4 (TLR4), and were enhanced by coadministration of the TLR3 agonist polyinosinic:polycytidylic acid. Together, these results indicate that gliadin peptide p31-43 activates the innate immune pathways in vivo, such as IFN-dependent inflammation, relevant to CD. Our findings also suggest a common mechanism for the potential interaction between dietary gluten and viral infections in the pathogenesis of CD. | - |
| dc.description | Fil: Araya, Romina Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina | - |
| dc.description | Fil: Gomez Castro, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina | - |
| dc.description | Fil: Carasi, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Departamento de Microbiología. Cátedra de Microbiología; Argentina | - |
| dc.description | Fil: McCarville, Justin L.. McMaster University; Canadá | - |
| dc.description | Fil: Jury, Jennifer. McMaster University; Canadá | - |
| dc.description | Fil: Mowat, Allan M.. University of Glasgow; Reino Unido | - |
| dc.description | Fil: Verdu, Elena F.. McMaster University; Canadá | - |
| dc.description | Fil: Chirdo, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Physiological Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1152/ajpgi.00435.2015 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/10.1152/ajpgi.00435.2015 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CELIAC DISEASE | - |
| dc.subject | INNATE IMMUNITY | - |
| dc.subject | P31-43 | - |
| dc.subject | POLYINOSINIC:POLYCYTIDYLIC ACID | - |
| dc.subject | SMALL INTESTINE | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Mechanisms of innate immune activation by gluten peptide p31-43 in mice | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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