Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Escudero, Graciela | - |
| dc.creator | Laino, Carlos Horacio | - |
| dc.creator | Martini, Nancy | - |
| dc.creator | Echeverría, Gustavo Alberto | - |
| dc.creator | Piro, Oscar Enrique | - |
| dc.creator | Williams, Patricia Ana María | - |
| dc.creator | Ferrer, Evelina Gloria | - |
| dc.date | 2018-12-26T19:19:28Z | - |
| dc.date | 2018-12-26T19:19:28Z | - |
| dc.date | 2017-05 | - |
| dc.date | 2018-10-22T22:00:41Z | - |
| dc.date.accessioned | 2019-04-29T15:46:02Z | - |
| dc.date.available | 2019-04-29T15:46:02Z | - |
| dc.date.issued | 2017-05 | - |
| dc.identifier | Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent; SciMedCentral; Annals of Medicinal Chemistry and Research; 3; 1017; 5-2017; 1-11 | - |
| dc.identifier | 2378-9336 | - |
| dc.identifier | http://hdl.handle.net/11336/66990 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301492 | - |
| dc.description | A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country. | - |
| dc.description | Fil: Escudero, Graciela. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; Argentina | - |
| dc.description | Fil: Laino, Carlos Horacio. Universidad de La Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Farmacia y Bioquimica; Argentina | - |
| dc.description | Fil: Martini, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina | - |
| dc.description | Fil: Echeverría, Gustavo Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina | - |
| dc.description | Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina | - |
| dc.description | Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina | - |
| dc.description | Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | SciMedCentral | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdf | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Antidepressant | - |
| dc.subject | Drug design | - |
| dc.subject | Sertraline derivative | - |
| dc.subject | Selective serotonin reuptake inhibitors | - |
| dc.subject | Bioavailability | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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