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dc.creatorMarin Burgin, Antonia-
dc.creatorKristan, William B.-
dc.creatorFrench, Kathleen A.-
dc.date2017-07-21T20:10:28Z-
dc.date2017-07-21T20:10:28Z-
dc.date2008-05-
dc.date2017-07-18T14:50:44Z-
dc.date.accessioned2019-04-29T15:46:03Z-
dc.date.available2019-04-29T15:46:03Z-
dc.date.issued2008-05-
dc.identifierMarin Burgin, Antonia; Kristan, William B.; French, Kathleen A.; From synapses to behavior: development of a sensory-motor circuit in the leech; John Wiley & Sons Inc; Developmental Neurobiology; 68; 6; 5-2008; 779-787-
dc.identifier1932-8451-
dc.identifierhttp://hdl.handle.net/11336/21126-
dc.identifier1932-846X-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301503-
dc.descriptionThe development of neuronal circuits has been advanced greatly by the use of imaging techniques that reveal the activity of neurons during the period when they are constructing synapses and forming circuits. This review focuses on experiments performed in leech embryos to characterize the development of a neuronal circuit that produces a simple segmental behavior called "local bending." The experiments combined electrophysiology, anatomy, and FRET-based voltage-sensitive dyes (VSDs). The VSDs offered two major advantages in these experiments: they allowed us to record simultaneously the activity of many neurons, and unlike other imaging techniques, they revealed inhibition as well as excitation. The results indicated that connections within the circuit are formed in a predictable sequence: initially neurons in the circuit are connected by electrical synapses, forming a network that itself generates an embryonic behavior and prefigures the adult circuit; later chemical synapses, including inhibitory connections, appear, "sculpting" the circuit to generate a different, mature behavior. In this developmental process, some of the electrical connections are completely replaced by chemical synapses, others are maintained into adulthood, and still others persist and share their targets with chemical synaptic connections.-
dc.descriptionFil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. University of California at San Diego; Estados Unidos-
dc.descriptionFil: Kristan, William B.. University of California at San Diego; Estados Unidos-
dc.descriptionFil: French, Kathleen A.. University of California at San Diego; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherJohn Wiley & Sons Inc-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/dneu.20551-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/dneu.20551-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectOtras Ciencias Médicas-
dc.subjectOtras Ciencias Médicas-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectOtras Ciencias Médicas-
dc.subjectOtras Ciencias Médicas-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleFrom synapses to behavior: development of a sensory-motor circuit in the leech-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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