Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Cerliani, Juan Pablo | - |
| dc.creator | Stowel, Sean R. | - |
| dc.creator | Mascanfroni, Ivan Darío | - |
| dc.creator | Arthur, Connie M. | - |
| dc.creator | Cummings, Richard D. | - |
| dc.creator | Rabinovich, Gabriel Adrian | - |
| dc.date | 2017-03-27T15:27:25Z | - |
| dc.date | 2017-03-27T15:27:25Z | - |
| dc.date | 2011-02 | - |
| dc.date | 2017-03-23T18:24:17Z | - |
| dc.date.accessioned | 2019-04-29T15:46:31Z | - |
| dc.date.available | 2019-04-29T15:46:31Z | - |
| dc.date.issued | 2011-02 | - |
| dc.identifier | Cerliani, Juan Pablo; Stowel, Sean R.; Mascanfroni, Ivan Darío; Arthur, Connie M.; Cummings, Richard D.; et al.; Expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity; Springer; Journal Of Clinical Immunology; 31; 1; 2-2011; 10-21 | - |
| dc.identifier | 0271-9142 | - |
| dc.identifier | http://hdl.handle.net/11336/14255 | - |
| dc.identifier | 1573-2592 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301672 | - |
| dc.description | Effective immunity relies on the recognition of pathogens and tumors by innate immune cells through diverse pattern recognition receptors (PRRs) that lead to initiation of signaling processes and secretion of pro- and anti-inflammatory cytokines. Galectins, a family of endogenous lectins widely expressed in infected and neoplastic tissues have emerged as part of the portfolio of soluble mediators and pattern recognition receptors responsible for eliciting and controlling innate immunity. These highly conserved glycan-binding proteins can control immune cell processes through binding to specific glycan structures on pathogens and tumors or by acting intracellularly via modulation of selective signaling pathways. Recent findings demonstrate that various galectin family members influence the fate and physiology of different innate immune cells including polymorphonuclear neutrophils, mast cells, macrophages, and dendritic cells. Moreover, several pathogens may actually utilize galectins as a mechanism of host invasion. In this review, we aim to highlight and integrate recent discoveries that have led to our current understanding of the role of galectins in host-pathogen interactions and innate immunity. Challenges for the future will embrace the rational manipulation of galectin-glycan interactions to instruct and shape innate immunity during microbial infections, inflammation, and cancer. | - |
| dc.description | Fil: Cerliani, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina | - |
| dc.description | Fil: Stowel, Sean R.. University Of Emory; Estados Unidos | - |
| dc.description | Fil: Mascanfroni, Ivan Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina | - |
| dc.description | Fil: Arthur, Connie M.. University Of Emory; Estados Unidos | - |
| dc.description | Fil: Cummings, Richard D.. University Of Emory; Estados Unidos | - |
| dc.description | Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Springer | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10875-010-9494-2 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10875-010-9494-2 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | GALECTINS | - |
| dc.subject | INNATE IMMUNITY | - |
| dc.subject | GLYCANS | - |
| dc.subject | DENDRITIC CELLS | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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