Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Papademetrio, Daniela Laura | - |
| dc.creator | Cavaliere, Victoria | - |
| dc.creator | Simunovich, Tania | - |
| dc.creator | Costantino, Susana Nora | - |
| dc.creator | Campos, Maria Dolores | - |
| dc.creator | Lombardo, Tomás | - |
| dc.creator | Fader Kaiser, Claudio Marcelo | - |
| dc.creator | Alvarez, Elida Ester | - |
| dc.date | 2016-04-11T14:28:01Z | - |
| dc.date | 2016-04-11T14:28:01Z | - |
| dc.date | 2013-04-16 | - |
| dc.date | 2016-05-06 15:52:43.262787-03 | - |
| dc.date.accessioned | 2019-04-29T15:46:45Z | - |
| dc.date.available | 2019-04-29T15:46:45Z | - |
| dc.date.issued | 2013-04-16 | - |
| dc.identifier | Papademetrio, Daniela Laura; Cavaliere, Victoria; Simunovich, Tania; Costantino, Susana Nora; Campos, Maria Dolores; et al.; Interplay between autophagy and apoptosis in pancreatic tumors in response to gemcitabine; Springer; Targeted Oncology; 9; 2; 16-4-2013; 123-134 | - |
| dc.identifier | 1776-2596 | - |
| dc.identifier | http://hdl.handle.net/11336/5111 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301775 | - |
| dc.description | Pancreatic cancer is an aggressive disease. Its incidence has increased over the last two decades. It is currently the fourth cause of death among cancers in the western world. Unfortunately, systemic chemotherapy still relies on just a few drugs which until now have produced unsatisfactory results. Gemcitabine (difluorodeoxycytidine) is currently the standard chemotherapy treatment at all stages of pancreatic adenocarcinoma. Survival benefit and clinical impact however remain moderate due to a high degree of intrinsic and acquired resistance. Autophagy plays an important role in cell death decision but can also protect cells from various apoptotic stimuli. We investigated the function of autophagy in pancreatic carcinoma cells, which are frequently insensitive to standard chemotherapeutic agents. Here, we demonstrate that autophagy is one of the mechanisms responsible for the refractory response of pancreatic tumors to gemcitabine. We present evidence in vitro and in vivo that proves autophagy plays a protective role in pancreatic ductal carcinoma cells, preventing them from entering the apoptotic pathway after stimulus with gemcitabine, thus contributing to treatment resistance. A better understanding of the role in the process may help in the discovery of new strategies to overcome tumor drug resistance in this aggressive disease. | - |
| dc.description | Fil: Papademetrio, Daniela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Cavaliere, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Simunovich, Tania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R .A. Margni"; Argentina | - |
| dc.description | Fil: Costantino, Susana Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R .A. Margni"; Argentina | - |
| dc.description | Fil: Campos, Maria Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Lombardo, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R .A. Margni"; Argentina | - |
| dc.description | Fil: Fader Kaiser, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto Histologia y Embriologia de Mendoza Dr. M. Burgos; Argentina | - |
| dc.description | Fil: Alvarez, Elida Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Inmunología; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Springer | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/ark/http://link.springer.com/article/10.1007%2Fs11523-013-0278-5 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1007/s11523-013-0278-5 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11523-013-0278-5 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | APOPTOSIS | - |
| dc.subject | AUTOPHAGY | - |
| dc.subject | DRUG RESISTANCE | - |
| dc.subject | PANCREATIC TUMOR | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Interplay between autophagy and apoptosis in pancreatic tumors in response to gemcitabine | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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