Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Ouyang, Jing | - |
| dc.creator | Plütschow, Annette | - |
| dc.creator | Von Strandmann, Elke Pogge | - |
| dc.creator | Reiners, Katrin S. | - |
| dc.creator | Ponader, Sabine | - |
| dc.creator | Rabinovich, Gabriel Adrian | - |
| dc.creator | Neuberg, Donna | - |
| dc.creator | Engert, Andreas | - |
| dc.creator | Shipp, Margaret A. | - |
| dc.date | 2015-10-06T18:48:27Z | - |
| dc.date | 2015-10-06T18:48:27Z | - |
| dc.date | 2013-04-25 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:46:47Z | - |
| dc.date.available | 2019-04-29T15:46:47Z | - |
| dc.date.issued | 2013-04-25 | - |
| dc.identifier | Ouyang, Jing; Plütschow, Annette; Von Strandmann, Elke Pogge; Reiners, Katrin S.; Ponader, Sabine; et al.; Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma; American Society of Hematology; Blood; 121; 17; 25-4-2013; 3431-3433 | - |
| dc.identifier | 0006-4971 | - |
| dc.identifier | http://hdl.handle.net/11336/2358 | - |
| dc.identifier | 1528-0020 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/301790 | - |
| dc.description | Galectin-1 (Gal1) is a member of a highly conserved family of carbohydrate-binding proteins that modulates innate and adaptive immune responses and fosters tumor-immune escape. Hodgkin lymphoma (HL) Reed-Sternberg (RS) cells overexpress and secrete Gal1, which selectively kills Th1,Th17 and cytotoxic T cells and promotes the immunosuppressive Th2/Treg-predominant HL microenvironment. We developed a sandwich ELISA and assessed serum Gal1 levels in 315 newly diagnosed, previously untreated HL patients enrolled on 3 risk-adapted clinical trials. Serum Gal1 levels were significantly higher in HL patients than in normal controls (p < .0001). Gal1 serum levels also increased with Ann Arbor stage (p < .0001), areas of nodal involvement (p = .0001) and the International Prognostic Score (IPS) (2-7, p = .006). We conclude that Gal1 serum levels are significantly associated with tumor burden and additional adverse clinical characteristics in newly diagnosed HL Patients. | - |
| dc.description | Fil: Ouyang, Jing. Dana-Farber Cancer Institute. Department of Medical Oncology; Estados Unidos de América; | - |
| dc.description | Fil: Plütschow, Annette. German Hodgkin Study Group; Alemania; | - |
| dc.description | Fil: Von Strandmann, Elke Pogge. University Hospital of Cologne. Laboratory for Immunotherapy; Alemania; | - |
| dc.description | Fil: Reiners, Katrin S.. University Hospital of Cologne. Laboratory for Immunotherapy; Alemania; | - |
| dc.description | Fil: Ponader, Sabine. German Hodgkin Study Group; Alemania; | - |
| dc.description | Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; | - |
| dc.description | Fil: Neuberg, Donna. Dana-Farber Cancer Institute. Department of Biostatistics; Estados Unidos de América; | - |
| dc.description | Fil: Engert, Andreas. German Hodgkin Study Group; Alemania; | - |
| dc.description | Fil: Shipp, Margaret A.. Dana-Farber Cancer Institute. Department of Medical Oncology; Estados Unidos de América; | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society of Hematology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1182/blood-2012-12-474569 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/121/17/3431.long | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | GALECTIN-1 | - |
| dc.subject | HODGKIN DISEASE | - |
| dc.subject | PROGNOSIS | - |
| dc.subject | ELISA | - |
| dc.subject | CASE CONTROL-STUDIES | - |
| dc.subject | NEOPLASM STAGING | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Oncología | - |
| dc.subject | Medicina Clínica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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