Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Agotegaray, Mariela Alejandra | - |
| dc.creator | Gumilar, Fernanda Andrea | - |
| dc.creator | Boeris, Monica | - |
| dc.creator | Toso, Ricardo Enrique | - |
| dc.creator | Minetti, Silvia Alejandra | - |
| dc.date | 2017-12-13T17:01:41Z | - |
| dc.date | 2017-12-13T17:01:41Z | - |
| dc.date | 2014-07 | - |
| dc.date | 2017-12-12T18:45:10Z | - |
| dc.date.accessioned | 2019-04-29T15:47:22Z | - |
| dc.date.available | 2019-04-29T15:47:22Z | - |
| dc.date.issued | 2014-07 | - |
| dc.identifier | Agotegaray, Mariela Alejandra; Gumilar, Fernanda Andrea; Boeris, Monica; Toso, Ricardo Enrique; Minetti, Silvia Alejandra; Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases; Hindawi Publishing Corporation; Biomedical Research International; 2014; 7-2014; 1-9; 505987 | - |
| dc.identifier | 2314-6133 | - |
| dc.identifier | http://hdl.handle.net/11336/30455 | - |
| dc.identifier | 2314-6141 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302042 | - |
| dc.description | Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal anti-inflammatory drug Fenoprofen and imidazole [Cu(fen)2(im)2] (Cu: copper(II) ion; fen: fenoprofenate anion from Fenoprofen, im: imidazole). A therapeutic dose of 28 mg/kg was tested for [Cu(fen)2(im)2] and 21 mg/kg was employed for Fenoprofen calcium, administered by oral gavage in female mice to compare the therapeutic properties of the new entity. The acetic acid induced writhing test was employed to study visceral pain. The percentage of inhibition in writhing and stretching was 78.9% and 46.2% for the [Cu(fen)2(im)2] and Fenoprofen calcium, respectively. This result indicates that the complex could be more effective in diminishing visceral pain. The formalin test was evaluated to study the impact of the drugs over nociceptive and inflammatory pain. The complex is a more potent analgesic on inflammatory pain than the parent drug. Ulcerogenic effects were evaluated using a model of gastric lesions induced by hypothermic-restraint stress. Fenoprofen calcium salt caused an ulcer index of about 79 mm2 while the one caused by [Cu(fen)2(im)2] was 22 mm2. The complex diminished the development of gastric mucosal ulcers in comparison to the uncomplexed drug. Possible mechanisms of action related to both therapeutic properties have been discussed. | - |
| dc.description | Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina | - |
| dc.description | Fil: Gumilar, Fernanda Andrea. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Boeris, Monica. Universidad Nacional de la Pampa. Facultad de Ciencias Veterinarias; Argentina | - |
| dc.description | Fil: Toso, Ricardo Enrique. Universidad Nacional de la Pampa. Facultad de Ciencias Veterinarias; Argentina | - |
| dc.description | Fil: Minetti, Silvia Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Hindawi Publishing Corporation | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2014/505987 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2014/505987/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/30455 | - |
| dc.subject | COMPLEJOS ANTIINFLAMATORIOS Cu | - |
| dc.subject | ANTIINFLAMATORIOS NO ESTEROIDALES | - |
| dc.subject | EFECTO ANTINOCICEPTIVO | - |
| dc.subject | EFECTO ANTIINFLAMATORIO | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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