Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Bragado, Paloma | - |
| dc.creator | Estrada, Yeriel | - |
| dc.creator | Parikh, Falguni | - |
| dc.creator | Krause, Sarah | - |
| dc.creator | Capobianco, Carla Sabrina | - |
| dc.creator | Farina, Hernán Gabriel | - |
| dc.creator | Schewe, Denis M. | - |
| dc.creator | Aguirre Ghiso, Julio A. | - |
| dc.date | 2017-09-22T18:40:13Z | - |
| dc.date | 2017-09-22T18:40:13Z | - |
| dc.date | 2013-09 | - |
| dc.date | 2017-09-21T18:54:15Z | - |
| dc.date.accessioned | 2019-04-29T15:47:23Z | - |
| dc.date.available | 2019-04-29T15:47:23Z | - |
| dc.date.issued | 2013-09 | - |
| dc.identifier | Bragado, Paloma; Estrada, Yeriel; Parikh, Falguni; Krause, Sarah; Capobianco, Carla Sabrina; et al.; TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling; Nature Publishing Group; Nature Cell Biology; 15; 11; 9-2013; 1351-1361 | - |
| dc.identifier | 1465-7392 | - |
| dc.identifier | http://hdl.handle.net/11336/24959 | - |
| dc.identifier | 1476-4679 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302054 | - |
| dc.description | In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis. This suggested that the BM might be a metastasis ‘restrictive soil’ by encoding dormancy-inducing cues in DTCs. Here we show in a head and neck squamous cell carcinoma (HNSCC) model that strong and specific transforming growth factor-β2 (TGF-β2) signalling in the BM activates the MAPK p38α/β, inducing an (ERK/p38)low signalling ratio. This results in induction of DEC2/SHARP1 and p27, downregulation of cyclin-dependent kinase 4 (CDK4) and dormancy of malignant DTCs. TGF-β2-induced dormancy required TGF-β receptor-I (TGF-β-RI), TGF-β-RIII and SMAD1/5 activation to induce p27. In lungs, a metastasis ‘permissive soil’ with low TGF-β2 levels, DTC dormancy was short-lived and followed by metastatic growth. Importantly, systemic inhibition of TGF-β-RI or p38α/β activities awakened dormant DTCs, fuelling multi-organ metastasis. Our work reveals a ‘seed and soil’ mechanism where TGF-β2 and TGF-β-RIII signalling through p38α/β regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis. | - |
| dc.description | Fil: Bragado, Paloma. Mount Sinai School of Medicine. Tisch Cancer Institute; Estados Unidos | - |
| dc.description | Fil: Estrada, Yeriel. Mount Sinai School of Medicine. Tisch Cancer Institute; Estados Unidos | - |
| dc.description | Fil: Parikh, Falguni. Mount Sinai School of Medicine. Tisch Cancer Institute; Estados Unidos | - |
| dc.description | Fil: Krause, Sarah. University Hospital of Schleswig-Holstein; Alemania | - |
| dc.description | Fil: Capobianco, Carla Sabrina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Schewe, Denis M.. Mount Sinai School of Medicine. Tisch Cancer Institute; Estados Unidos | - |
| dc.description | Fil: Aguirre Ghiso, Julio A.. Mount Sinai School of Medicine. Tisch Cancer Institute; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/ncb2861 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/ncb/journal/v15/n11/full/ncb2861.html | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006312/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/24959 | - |
| dc.subject | p38 MAP KINASE | - |
| dc.subject | DORMANCY | - |
| dc.subject | CANCER | - |
| dc.subject | TGF | - |
| dc.subject | DTC | - |
| dc.subject | Quiescence | - |
| dc.subject | Target organ | - |
| dc.subject | Seed and soil | - |
| dc.subject | Metastasis | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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