Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Rohr, Cristian Oscar | - |
| dc.creator | Gonzalo Parra, R. | - |
| dc.creator | Yankilevich, Patricio | - |
| dc.creator | Perez Castro, Carolina Ines | - |
| dc.date | 2017-02-01T15:40:44Z | - |
| dc.date | 2017-02-01T15:40:44Z | - |
| dc.date | 2013-10 | - |
| dc.date | 2016-12-12T20:46:30Z | - |
| dc.date.accessioned | 2019-04-29T15:47:44Z | - |
| dc.date.available | 2019-04-29T15:47:44Z | - |
| dc.date.issued | 2013-10 | - |
| dc.identifier | Rohr, Cristian Oscar; Gonzalo Parra, R.; Yankilevich, Patricio; Perez Castro, Carolina Ines; INSECT: In silico search for co-occurring transcription factors; Oxford University Press; Bioinformatics (oxford, England); 29; 22; 10-2013; 2852-2858 | - |
| dc.identifier | 1367-4803 | - |
| dc.identifier | http://hdl.handle.net/11336/12301 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302218 | - |
| dc.description | P. Yankilevich & C Perez Castro both corresponding authors. Motivation: Transcriptional regulation occurs through the concerted actions of multiple transcription factors (TFs) that bind cooperatively to cis-regulatory modules (CRMs) of genes. These CRMs usually contain a variable number of transcription factor-binding sites(TFBSs) involved in related cellular and physiological processes. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) has been effective in detecting TFBSs and nucleosome location in order to identify potential CRMs in genome-wide studies. Although several attempts were previously reported to predict the potential binding of TFs at TFBSs within CRMs by comparing different ChIP-seq data, these have been hampered by excessive background, usually emerging as a consequence of experimental conditions. To understand these complex regulatory circuits, it would be helpful to have reliable and updated user-friendly tools to assist in the identification of TFBSs and CRMs for genes of interest. Results: Here we present INSECT (IN-silico SEarch for Co-occurring Transcription factors), a novel web server for identifying potential TFBSs and CRMs in gene sequences. By combining several strategies, INSECT provides flexible analysis of multiple co-occurring TF binding sites, by applying differing search schemes and restriction parameters. Availability: INSECT is freely available as a web server at http://bioinformatics.ibioba-mpsp-conicet.gov.ar/INSECT | - |
| dc.description | Fil: Rohr, Cristian Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina | - |
| dc.description | Fil: Gonzalo Parra, R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina | - |
| dc.description | Fil: Yankilevich, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina | - |
| dc.description | Fil: Perez Castro, Carolina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Oxford University Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bioinformatics/article/29/22/2852/316096/INSECT-IN-silico-SEarch-for-Co-occurring | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/bioinformatics/btt506 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/12301 | - |
| dc.subject | Sequence Analysis | - |
| dc.subject | Motif finding | - |
| dc.subject | Bioinformatics | - |
| dc.subject | Ciencias de la Información y Bioinformática | - |
| dc.subject | Ciencias de la Computación e Información | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | INSECT: In silico search for co-occurring transcription factors | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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