Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Fernández Hurst, Nicolás | - |
| dc.creator | Bibolini, Mario Javier | - |
| dc.creator | Roth, German Alfredo | - |
| dc.date | 2018-07-02T18:04:50Z | - |
| dc.date | 2018-07-02T18:04:50Z | - |
| dc.date | 2015-08 | - |
| dc.date | 2018-06-29T16:45:05Z | - |
| dc.date.accessioned | 2019-04-29T15:47:55Z | - |
| dc.date.available | 2019-04-29T15:47:55Z | - |
| dc.date.issued | 2015-08 | - |
| dc.identifier | Fernández Hurst, Nicolás; Bibolini, Mario Javier; Roth, German Alfredo; Diazepam inhibits proliferation of lymph node cells isolated from rats with experimental autoimmune encephalomyelitis; Karger; NeuroImmunoModulation; 22; 5; 8-2015; 293-302 | - |
| dc.identifier | 1021-7401 | - |
| dc.identifier | http://hdl.handle.net/11336/50869 | - |
| dc.identifier | 1423-0216 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302303 | - |
| dc.description | Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to human multiple sclerosis involving peripheral activation of autoreactive T cells which infiltrate the central nervous system and react to self antigens leading to damage. In previous studies, we have demonstrated that treatment with diazepam decreases the incidence and histological signs associated with the disease and diminishes immunological responses. The aim of the present work was to evaluate direct effects of diazepam on isolated T cells involved in immune responses during the development of EAE. Methods: Animals were sensitized with whole myelin to induce EAE and sacrificed during the acute phase of the disease. In mononuclear cells isolated from popliteal lymph nodes, cell viability, apoptosis induction, proliferation and cytokine production were evaluated. Results: Diazepam did not have a toxic or proapoptotic effect on the cells, at least up to the concentration of 25 μM, but proliferation, CD8+ T-cell activation and proinflammatory cytokine production were dose-dependently decreased. Conclusions: Diazepam has a direct inhibitory effect on the proliferation and activation of T lymphocytes isolated from the main lymphoid organ involved in disease onset and this could be one of the mechanisms that contribute to the beneficial effect previously observed with diazepam in vivo during EAE development. | - |
| dc.description | Fil: Fernández Hurst, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina | - |
| dc.description | Fil: Bibolini, Mario Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina | - |
| dc.description | Fil: Roth, German Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Karger | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/369277 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1159/000369277 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/50869 | - |
| dc.subject | AUTOIMMUNITY | - |
| dc.subject | BENZODIAZEPINES | - |
| dc.subject | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | - |
| dc.subject | MYELIN BASIC PROTEIN | - |
| dc.subject | T LYMPHOCYTES | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Diazepam inhibits proliferation of lymph node cells isolated from rats with experimental autoimmune encephalomyelitis | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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