Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Montanari, Sonia | - |
| dc.creator | Dayan, Victor | - |
| dc.creator | Yannarelli, Gustavo Gabriel | - |
| dc.creator | Billia, Filio | - |
| dc.creator | Viswanathan, Sowmya | - |
| dc.creator | Connelly, Kim A. | - |
| dc.creator | Keating, Armand | - |
| dc.date | 2018-04-17T17:08:11Z | - |
| dc.date | 2018-04-17T17:08:11Z | - |
| dc.date | 2015-11 | - |
| dc.date | 2018-04-17T13:49:02Z | - |
| dc.date.accessioned | 2019-04-29T15:48:00Z | - |
| dc.date.available | 2019-04-29T15:48:00Z | - |
| dc.date.issued | 2015-11 | - |
| dc.identifier | Montanari, Sonia; Dayan, Victor; Yannarelli, Gustavo Gabriel; Billia, Filio; Viswanathan, Sowmya; et al.; Mesenchymal stromal cells improve cardiac function and left ventricular remodeling in a heart transplantation model; Elsevier Science Inc; Journal of Heart and Lung Transplantation; 34; 11; 11-2015; 1481-1488 | - |
| dc.identifier | 1053-2498 | - |
| dc.identifier | http://hdl.handle.net/11336/42282 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302346 | - |
| dc.description | Background: Ischemia/reperfusion (I/R) injury is an inevitable consequence of organ transplantation and a major determinant of patient and graft survival in heart transplantation. Bone marrow–mesenchymal stromal cell (BM-MSC) treatment is a potentially effective cell therapy for cardiac disease. We investigated the effects of intravenous delivery of BM-MSCs in the acute phase post-transplant in a heterotopic heart transplantation (HHT) model associated with I/R injury. Methods: Hearts of wild-type Lewis (WT LEW) rats were harvested and transplanted heterotopically into the necks of recipient WT LEW rats. Forty-eight hours after HHT, BM-MSCs were injected intravenously into animals in the experimental group, whereas controls received normal saline (NS). Results: Eight days after BM-MSC injection, fractional shortening of transplanted hearts was significantly higher and left ventricular systolic diameter was lower in the BM-MSC group compared with controls, whereas no differences were found 28 days after infusion. A reduction in ventricular remodeling and cardiac fibrosis was observed by histochemical analysis and confirmed by cardiac magnetic resonance imaging in the BM-MSC group. The perivascular stromal cells’ density and the number of capillaries were increased whereas the number of apoptotic cells decreased significantly in transplanted hearts in the BM-MSC group compared with the NS group. Conclusions: We showed early improvement in cardiac function and subsequent enhanced ventricular remodeling, reduced cardiac fibrosis, augmented neo-vascularization and decreased cardiomyocyte apoptosis of the transplanted heart in a heterotopic transplantation model after intravenous infusion of BM-derived MSCs. Our data suggest that clinical studies with BM-MSCs are warranted to understand their effects on cardiac graft and transplant recipient survival. | - |
| dc.description | Fil: Montanari, Sonia. University Health Network; Canadá. University of Toronto; Canadá | - |
| dc.description | Fil: Dayan, Victor. University Health Network; Canadá | - |
| dc.description | Fil: Yannarelli, Gustavo Gabriel. University Health Network; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Billia, Filio. Toronto General Hospital; Canadá | - |
| dc.description | Fil: Viswanathan, Sowmya. University Health Network; Canadá | - |
| dc.description | Fil: Connelly, Kim A.. Keenan Research Centre; Canadá | - |
| dc.description | Fil: Keating, Armand. University Health Network; Canadá. University of Toronto; Canadá | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.healun.2015.05.008 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1053249815012796 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/42282 | - |
| dc.subject | MESENCHYMAL STROMAL CELLS | - |
| dc.subject | HEART TRANSPLANTATION | - |
| dc.subject | REMODELING | - |
| dc.subject | Otras Biotecnologías de la Salud | - |
| dc.subject | Biotecnología de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Mesenchymal stromal cells improve cardiac function and left ventricular remodeling in a heart transplantation model | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.