Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Dresch, R. R. | - |
| dc.creator | Zanetti, G. D. | - |
| dc.creator | Irazoqui, Fernando Jose | - |
| dc.creator | Sendra, Victor German | - |
| dc.creator | Zlocowski, Natacha | - |
| dc.creator | Bernardi, A. | - |
| dc.creator | Rosa, R. M. | - |
| dc.creator | Battastini, A. M. O. | - |
| dc.creator | Henriques, Amalia Teresinha | - |
| dc.creator | Vozári Hampe, M. M. | - |
| dc.date | 2017-09-22T19:17:09Z | - |
| dc.date | 2017-09-22T19:17:09Z | - |
| dc.date | 2012-09 | - |
| dc.date | 2017-08-09T14:24:32Z | - |
| dc.date.accessioned | 2019-04-29T15:48:12Z | - |
| dc.date.available | 2019-04-29T15:48:12Z | - |
| dc.date.issued | 2012-09 | - |
| dc.identifier | Dresch, R. R.; Zanetti, G. D.; Irazoqui, Fernando Jose; Sendra, Victor German; Zlocowski, Natacha; et al.; Staining tumor cells with biotinylated ACL-I, a lectin isolated from the marine sponge, Axinella corrugata; Taylor & Francis; Biotechnic And Histochemistry; 88; 1; 9-2012; 1-9 | - |
| dc.identifier | 1052-0295 | - |
| dc.identifier | http://hdl.handle.net/11336/24985 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302443 | - |
| dc.description | Axinella corrugata lectin 1 (ACL-1) was purifi ed from aqueous extracts of the marine sponge, Axinella corrugata . ACL-1 strongly agglutinates native rabbit erythrocytes. The hemagglutination is inhibited by N -acetyl derivatives, particularly N , N ’ , N ” -triacetylchitotriose, N -acetyl-Dglucosamine, N -acetyl-D-mannosamine and N -acetyl-D-galactosamine. We investigated the capacity of biotinylated ACL-1 to stain several transformed cell lines including breast (T-47D, MCF7), colon (HT-29), lung (H460), ovary (OVCAR-3) and bladder (T24). ACL-I may bind to both monosaccharides and oligosaccharides of tumor cells, N -acetyl-D-galactosamine, and N -acetyl-Dglucosamine glycan types. The lectins are useful, not only as markers and diagnostic parameters, but also for tissue mapping in suspicious neoplasms. In addition, they provide a better understanding of neoplasms at the cytological and molecular levels. Furthermore, the use of potential metastatic markers such as lectins is crucial for developing successful tools for therapy against cancer. We observed that biotinylated ACL-I stains tumor cells and may hold potential as a probe for identifying transformed cells and for studying glycan structures synthesized by such cells. | - |
| dc.description | Fil: Dresch, R. R.. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Zanetti, G. D.. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Irazoqui, Fernando Jose. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Sendra, Victor German. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Zlocowski, Natacha. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Bernardi, A.. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Rosa, R. M.. Universidade Luterana do Brasil; Brasil | - |
| dc.description | Fil: Battastini, A. M. O.. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Henriques, Amalia Teresinha. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Vozári Hampe, M. M.. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Taylor & Francis | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10520295.2012.717304 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10520295.2012.717304 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/31204 | - |
| dc.subject | AXINELLA CORRUGATA | - |
| dc.subject | CANCER | - |
| dc.subject | CARBOHYDRATE | - |
| dc.subject | LECTIN | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Staining tumor cells with biotinylated ACL-I, a lectin isolated from the marine sponge, Axinella corrugata | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.