Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Capasso, Dario Nicolás | - |
| dc.creator | Pepe, María Victoria | - |
| dc.creator | Rossello, Jéssica | - |
| dc.creator | Lepanto, Paola | - |
| dc.creator | Arias, Paula Alejandra | - |
| dc.creator | Salzman, Valentina | - |
| dc.creator | Kierbel, Arlinet Verónica | - |
| dc.date | 2018-07-16T19:08:09Z | - |
| dc.date | 2018-07-16T19:08:09Z | - |
| dc.date | 2016-12 | - |
| dc.date | 2018-06-19T16:55:27Z | - |
| dc.date.accessioned | 2019-04-29T15:48:19Z | - |
| dc.date.available | 2019-04-29T15:48:19Z | - |
| dc.date.issued | 2016-12 | - |
| dc.identifier | Capasso, Dario Nicolás; Pepe, María Victoria; Rossello, Jéssica; Lepanto, Paola; Arias, Paula Alejandra; et al.; Elimination of Pseudomonas aeruginosa through Efferocytosis upon Binding to Apoptotic Cells; Public Library of Science; Plos Pathogens; 12; 12; 12-2016; 1-22; e1006068 | - |
| dc.identifier | http://hdl.handle.net/11336/52273 | - |
| dc.identifier | 1553-7366 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302497 | - |
| dc.description | For opportunistic pathogens such as Pseudomonas aeruginosa, the mucosal barrier represents a formidable challenge. Infections develop only in patients with altered epithelial barriers. Here, we showed that P. aeruginosa interacts with a polarized epithelium, adhering almost exclusively at sites of multi-cellular junctions. In these sites, numerous bacteria attach to an extruded apoptotic cell or apoptotic body. This dead cell tropism is independent of the type of cell death, as P. aeruginosa also binds to necrotic cells. We further showed that P. aeruginosa is internalized through efferocytosis, a process in which surrounding epithelial cells engulf and dispose of extruded apoptotic cells. Intracellularly, along with apoptotic cell debris, P. aeruginosa inhabits an efferocytic phagosome that acquires lysosomal features, and is finally killed. We propose that elimination of P. aeruginosa through efferocytosis is part of a host defense mechanism. Our findings could be relevant for the study of cystic fibrosis, which is characterized by an exacerbated number of apoptotic cells and ineffective efferocytosis. | - |
| dc.description | Fil: Capasso, Dario Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina | - |
| dc.description | Fil: Pepe, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina | - |
| dc.description | Fil: Rossello, Jéssica. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.description | Fil: Lepanto, Paola. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.description | Fil: Arias, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina | - |
| dc.description | Fil: Salzman, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina | - |
| dc.description | Fil: Kierbel, Arlinet Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Public Library of Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.ppat.1006068 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006068 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/7125 | - |
| dc.subject | PSEUDOMONAS | - |
| dc.subject | ESFFEROCYTOSIS | - |
| dc.subject | APOPTOSIS | - |
| dc.subject | PSEUDOMONAS | - |
| dc.subject | ESFFEROCYTOSIS | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Elimination of Pseudomonas aeruginosa through Efferocytosis upon Binding to Apoptotic Cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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