Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Espada, Rocío | - |
| dc.creator | Ferreiro, Diego | - |
| dc.creator | Parra, Rodrigo Gonzalo | - |
| dc.date | 2018-08-14T17:48:12Z | - |
| dc.date | 2018-08-14T17:48:12Z | - |
| dc.date | 2017-03 | - |
| dc.date | 2018-08-13T18:30:59Z | - |
| dc.date.accessioned | 2019-04-29T15:48:34Z | - |
| dc.date.available | 2019-04-29T15:48:34Z | - |
| dc.date.issued | 2017-03 | - |
| dc.identifier | Espada, Rocío; Ferreiro, Diego; Parra, Rodrigo Gonzalo; The Design of Repeat Proteins: Stability Conflicts with Functionality; Insight Medical Publishing; Biochemistry & Molecular Biology Journal; 3; 1; 3-2017; 1-5 | - |
| dc.identifier | 2471-8084 | - |
| dc.identifier | http://hdl.handle.net/11336/55433 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302618 | - |
| dc.description | Repeat proteins are constituted by a variable number of copies of a given structural element that is tandemly repeated along a longitudinal axis. They mainly function as protein-protein interactors with binding interfaces that are not conserved along members of the same family but specific for each interacting pair. These proteins have been extensively used as scaffolds for protein design that are usually centered on the maximization of the stability of the repeat arrays. Although overall stability is important for obtaining molecules with enhanced solubility and expression, natural occurring repeatproteins have unstable characteristics that are relevant for their binding properties. Here we discuss the state of the art for repeat protein designs and the ideas of allowing energetic conflicts for introducing enhanced functionality in the arrays. | - |
| dc.description | Fil: Espada, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina | - |
| dc.description | Fil: Ferreiro, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina | - |
| dc.description | Fil: Parra, Rodrigo Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Max Planck Institute For Biophysical Chemistry; Alemania | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Insight Medical Publishing | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.21767/2471-8084.100031 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://biochem-molbio.imedpub.com/the-design-of-repeat-proteins-stability-conflicts-with-functionality.php?aid=18884 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/56799 | - |
| dc.subject | Repeat proteins | - |
| dc.subject | Protein folding | - |
| dc.subject | Designed proteins | - |
| dc.subject | Protein stability | - |
| dc.subject | Local frustration | - |
| dc.subject | Ciencias de la Computación | - |
| dc.subject | Ciencias de la Computación e Información | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | The Design of Repeat Proteins: Stability Conflicts with Functionality | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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