Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Sbaraglini, Maria Laura | - |
| dc.creator | Talevi, Alan | - |
| dc.date | 2018-08-13T19:07:26Z | - |
| dc.date | 2018-08-13T19:07:26Z | - |
| dc.date | 2017-04 | - |
| dc.date | 2018-08-13T14:39:23Z | - |
| dc.date.accessioned | 2019-04-29T15:49:12Z | - |
| dc.date.available | 2019-04-29T15:49:12Z | - |
| dc.date.issued | 2017-04 | - |
| dc.identifier | Sbaraglini, Maria Laura; Talevi, Alan; Hybrid compounds as anti-infective agents; Bentham Science Publishers; Current Topics in Medicinal Chemistry; 17; 9; 4-2017; 1080-1095 | - |
| dc.identifier | 1568-0266 | - |
| dc.identifier | http://hdl.handle.net/11336/55197 | - |
| dc.identifier | 1873-4294 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302897 | - |
| dc.description | Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance linked to single gene product. Although less frequently explored, they could also be useful in the treatment of frequently occurring co-infections. Here, we overview recent advances in the field of hybrid antimicrobials. Furthermore, we discuss some cutting-edge approaches to face the development of designed multi-target agents in the era of omics and big data, namely analysis of gene signatures and multitask QSAR models. | - |
| dc.description | Fil: Sbaraglini, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina | - |
| dc.description | Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Bentham Science Publishers | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1568026616666160927160912 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/145866/article | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ANTI-INFECTIVE | - |
| dc.subject | ANTIBIOTIC | - |
| dc.subject | ANTIFUNGAL | - |
| dc.subject | ANTIMICROBIAL | - |
| dc.subject | ANTIMICROBIAL RESISTANCE | - |
| dc.subject | ANTIVIRAL | - |
| dc.subject | CHIMERIC MOLECULE | - |
| dc.subject | HYBRID DRUG | - |
| dc.subject | HYBRID MOLECULE | - |
| dc.subject | MULTI-TARGET AGENTS | - |
| dc.subject | MULTI-TARGET DRUG | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Hybrid compounds as anti-infective agents | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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