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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Pansa, Maria Florencia | - |
| dc.creator | Lamberti, María Julia | - |
| dc.creator | Cogno, Ingrid Sol | - |
| dc.creator | Correa, Silvia Graciela | - |
| dc.creator | Rumie Vittar, Natalia Belen | - |
| dc.creator | Rivarola, Viviana Alicia | - |
| dc.date | 2019-03-14T17:20:22Z | - |
| dc.date | 2019-03-14T17:20:22Z | - |
| dc.date | 2016-01 | - |
| dc.date | 2019-03-13T17:48:29Z | - |
| dc.date.accessioned | 2019-04-29T15:49:22Z | - |
| dc.date.available | 2019-04-29T15:49:22Z | - |
| dc.date.issued | 2016-01 | - |
| dc.identifier | Pansa, Maria Florencia; Lamberti, María Julia; Cogno, Ingrid Sol; Correa, Silvia Graciela; Rumie Vittar, Natalia Belen; et al.; Contribution of resident and recruited macrophages to the photodynamic intervention of colorectal tumor microenvironment; Karger; Tumor Biology; 37; 1; 1-2016; 541-552 | - |
| dc.identifier | 1010-4283 | - |
| dc.identifier | http://hdl.handle.net/11336/71644 | - |
| dc.identifier | 1423-0380 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302973 | - |
| dc.description | The study of cellular interactions in the tumor microenvironment has become one of the main areas of research in the fight against cancer. Tumor-associated macrophages (TAMs) influence tumor progression and therapy response due to its functional plasticity. Regarding cancer treatment, photodynamic therapy (PDT) is a minimally invasive and clinically approved procedure that involves the administration of a photosensitizer (PS), a nontoxic photosensitizing drug which is selectively retained in neoplastic tissue. Here, we investigated the role of resident and nonresident macrophages in the context of a PDT-treated colorectal tumor by developing a combination of 2-D and three-dimensional (3-D) experimental platform, recreating tumor-stroma interactions in vitro. Enhancement of cytotoxicity of PDT was achieved in the presence of nonresident macrophages which had a strong anti-tumor phenotype mediated by the production of nitric oxide, IL-6, and tumor necrosis factor alpha (TNF-α). On the contrary, tumor resident macrophages induced a pro-tumor phenotype promoting tumor cell migration and endothelial stimulation. Due to their plasticity, tumor-resident or tumor-recruited macrophages can differentially influence the response of tumors to PDT, so their multifactorial roles should be considered in the overall design of anti-tumor therapeutic. | - |
| dc.description | Fil: Pansa, Maria Florencia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina | - |
| dc.description | Fil: Lamberti, María Julia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; Argentina | - |
| dc.description | Fil: Cogno, Ingrid Sol. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; Argentina | - |
| dc.description | Fil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina | - |
| dc.description | Fil: Rumie Vittar, Natalia Belen. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; Argentina | - |
| dc.description | Fil: Rivarola, Viviana Alicia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Karger | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s13277-015-3768-5 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs13277-015-3768-5 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | COLORECTAL CANCER | - |
| dc.subject | MACROPHAGES | - |
| dc.subject | PHOTODYNAMIC THERAPY | - |
| dc.subject | TAMS | - |
| dc.subject | TUMOR MICROENVIRONMENT | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Contribution of resident and recruited macrophages to the photodynamic intervention of colorectal tumor microenvironment | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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