Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Pontillo, Carolina Andrea | - |
| dc.creator | Rojas, Paola Andrea | - |
| dc.creator | Chiappini, Florencia Ana | - |
| dc.creator | Sequeira, Gonzalo Ricardo | - |
| dc.creator | Cocca, Claudia Marcela | - |
| dc.creator | Crocci, Máximo | - |
| dc.creator | Colombo, Lucas Luis | - |
| dc.creator | Lanari, Claudia Lee Malvina | - |
| dc.creator | Kleiman de Pisarev, Diana | - |
| dc.creator | Randi, Andrea Silvana | - |
| dc.date | 2015-08-25T19:11:29Z | - |
| dc.date | 2015-08-25T19:11:29Z | - |
| dc.date | 2013-05 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:49:25Z | - |
| dc.date.available | 2019-04-29T15:49:25Z | - |
| dc.date.issued | 2013-05 | - |
| dc.identifier | Pontillo, Carolina Andrea; Rojas, Paola Andrea; Chiappini, Florencia Ana; Sequeira, Gonzalo Ricardo; Cocca, Claudia Marcela; et al.; Action of Hexachlorobenzene on tumor growth and metastasis in different experimental models; Elsevier; Toxicology and Applied Pharmacology; 268; 3; 5-2013; 331-342 | - |
| dc.identifier | 0041-008X | - |
| dc.identifier | http://hdl.handle.net/11336/1816 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/302992 | - |
| dc.description | Hexachlorobenzene (HCB) is a widespread organochlorine pesticide, considered a possible human carcinogen. It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR). We have found that HCB activates c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration, in an AhR-dependent manner in MDA-MB-231 breast cancer cells. The aim of this study was to investigate in vitro the effect of HCB (0.005, 0.05, 0.5, 5μM) on cell invasion and metalloproteases (MMPs) 2 and 9 activation in MDA-MB-231 cells. Furthermore, we examined in vivo the effect of HCB (0.3, 3, 30mg/kg b.w.) on tumor growth, MMP2 and MMP9 expression, and metastasis using MDA-MB-231 xenografts and two syngeneic mouse breast cancer models (spontaneous metastasis using C4-HI and lung experimental metastasis using LM3). Our results show that HCB (5μM) enhances MMP2 expression, as well as cell invasion, through AhR, c-Src/HER1 pathway and MMPs. Moreover, HCB increases MMP9 expression, secretion and activity through a HER1 and AhR-dependent mechanism, in MDA-MB-231 cells. HCB (0.3 and 3mg/kg b.w.) enhances subcutaneous tumor growth in MDA-MB-231 and C4-HI in vivo models. In vivo, using MDA-MB-231 model, the pesticide (0.3, 3 and 30mg/kg b.w.) activated c-Src, HER1, STAT5b, and ERK1/2 signaling pathways and increased MMP2 and MMP9 protein levels. Furthermore, we observed that HCB stimulated lung metastasis regardless the tumor hormone-receptor status. Our findings suggest that HCB may be a risk factor for human breast cancer progression. | - |
| dc.description | Fil: Pontillo, Carolina Andrea. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina; | - |
| dc.description | Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; | - |
| dc.description | Fil: Chiappini, Florencia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas . Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina; | - |
| dc.description | Fil: Sequeira, Gonzalo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; | - |
| dc.description | Fil: Cocca, Claudia Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Físico Matemática; Argentina; | - |
| dc.description | Fil: Crocci, Máximo. Instituto de Inmunooncología Crescenti; Argentina; | - |
| dc.description | Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina; | - |
| dc.description | Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; | - |
| dc.description | Fil: Kleiman de Pisarev, Diana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina; | - |
| dc.description | Fil: Randi, Andrea Silvana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina; | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0041008X1300077X | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1016/j.taap.2013.02.007 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Hexachlorobenzene | - |
| dc.subject | MDA-MB-231 | - |
| dc.subject | Cell invasion; | - |
| dc.subject | AhR | - |
| dc.subject | MMPs | - |
| dc.subject | Metastasis. | - |
| dc.subject | Oncología | - |
| dc.subject | Medicina Clínica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Action of Hexachlorobenzene on tumor growth and metastasis in different experimental models | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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