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dc.creatorRéjiba, Samia-
dc.creatorMercuri, Paola Sandra-
dc.creatorPower, Pablo-
dc.creatorKechrid, Amel-
dc.date2017-02-20T19:34:04Z-
dc.date2017-02-20T19:34:04Z-
dc.date2011-04-
dc.date2017-02-15T14:08:31Z-
dc.date.accessioned2019-04-29T15:49:28Z-
dc.date.available2019-04-29T15:49:28Z-
dc.date.issued2011-04-
dc.identifierRéjiba, Samia; Mercuri, Paola Sandra; Power, Pablo; Kechrid, Amel; Emergence and dominance of CTX-M-15 extended spectrum beta-lactamase among Escherichia coli isolates from children; Mary Ann Liebert Inc; Microbial Drug Resistance-mechanisms Epidemiology And Disease; 17; 2; 4-2011; 135-140-
dc.identifier1076-6294-
dc.identifierhttp://hdl.handle.net/11336/13184-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303015-
dc.descriptionOf forty-seven extended-spectrum cephalosporin-resistant Escherichia coli isolates, collected from children at the Children’s Hospital in 2006 (Tunis, Tunisia), we analyzed 32 isolates that were genotypically different by enterobacterial repetitive intergenic consensus -polymerase chain reaction. For all isolates, the double-disk diffusion test revealed synergy between clavulanate and cefotaxime and/or ceftazidime, suggesting the production of extended-spectrum beta-lactamases. Polymerase chain reaction experiments, performed on plasmid DNA, and sequencing revealed the presence of blaTEM-1B (26 isolates, 81%), blaTEM-34(IRT-6) (3 isolates, 9%), blaSHV-12 (2 isolates, 6%), and blaCTX-M-15 (31 isolates, 97%). Further, the insertion sequence ISEcp1 was found upstream from the blaCTX-M-15 gene in 11 isolates. The bla genes were found alone or in various combinations in a single isolate. blaTEM-1B and blaCTX-M-15 genes were detected in 26 out of the 32 isolates. Three isolates harbored both blaTEM-34(IRT-6) and blaCTX-M-15. blaSHV-12 was identified either alone or with blaCTX-M-15 in a single isolate. Our investigation showed the dominance of CTX-M-type extended-spectrum beta-lactamases, with CTX-M-15 particularly common, and to our best knowledge, this is the first report of the coexistence of CTX-M-15 and IRT-6 in E. coli isolates from children in Tunisia.-
dc.descriptionFil: Réjiba, Samia. Université Tunis El-Manar; Túnez. Hôpital d’Enfants; Túnez-
dc.descriptionFil: Mercuri, Paola Sandra. Universite de Liege; Bélgica-
dc.descriptionFil: Power, Pablo. Universite de Liege; Bélgica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina-
dc.descriptionFil: Kechrid, Amel. Hôpital d’Enfants; Túnez-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherMary Ann Liebert Inc-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/mdr.2010.0098-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/mdr.2010.0098-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectmicrobial drug resistance-
dc.subjectmechanisms-
dc.subjectESBL-
dc.subjectmolecular characterization-
dc.subjectEnfermedades Infecciosas-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleEmergence and dominance of CTX-M-15 extended spectrum beta-lactamase among Escherichia coli isolates from children-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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