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Campo DC Valor Lengua/Idioma
dc.creatorAlonso Padilla, Julio-
dc.creatorGallego, Montserrat-
dc.creatorSchijman, Alejandro Gabriel-
dc.creatorGascon, Joaquim-
dc.date2018-04-05T19:20:04Z-
dc.date2018-04-05T19:20:04Z-
dc.date2017-06-
dc.date2018-04-05T13:46:21Z-
dc.date.accessioned2019-04-29T15:49:28Z-
dc.date.available2019-04-29T15:49:28Z-
dc.date.issued2017-06-
dc.identifierAlonso Padilla, Julio; Gallego, Montserrat; Schijman, Alejandro Gabriel; Gascon, Joaquim; Molecular diagnostics for Chagas disease: up to date and novel methodologies; Expert Reviews; Expert Review of Molecular Diagnostics; 17; 7; 6-2017; 699-710-
dc.identifier1473-7159-
dc.identifierhttp://hdl.handle.net/11336/40966-
dc.identifier1744-8352-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303016-
dc.descriptionIntroduction: Chagas disease is caused by the parasite Trypanosoma cruzi. It affects 7 million people, mainly in Latin America. Diagnosis is usually made serologically, but at some clinical scenarios serology cannot be used. Then, molecular detection is required for early detection of congenital transmission, treatment response follow up, and diagnosis of immune-suppression reactivation. However, present tests are technically demanding and require well-equipped laboratories which make them unfeasible in low-resources endemic regions. Areas covered: Available molecular tools for detection of T. cruzi DNA, paying particular attention to quantitative PCR protocols, and to the latest developments of user-friendly molecular diagnostic methodologies. Expert commentary: In the absence of appropriate biomarkers, molecular diagnosis is the only option for the assessment of treatment response. Besides, it is very useful for the early detection of acute infections, like congenital cases. Since current Chagas disease molecular tests are restricted to referential labs, research efforts must focus in the implementation of easy-to-use diagnostic tools in order to overcome the access to diagnosis gap.-
dc.descriptionFil: Alonso Padilla, Julio. Universidad de Barcelona; España-
dc.descriptionFil: Gallego, Montserrat. Universidad de Barcelona; España-
dc.descriptionFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina-
dc.descriptionFil: Gascon, Joaquim. Universidad de Barcelona; España-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherExpert Reviews-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://doi.org/10.1080/14737159.2017.1338566-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14737159.2017.1338566-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectCHAGAS DISEASE-
dc.subjectISOTHERMAL AMPLIFICATION-
dc.subjectMOLECULAR DETECTION-
dc.subjectPOINT-OF-CARE-
dc.subjectQUANTITATIVE PCR-
dc.subjectTRYPANOSOMA CRUZI-
dc.subjectSalud Ocupacional-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleMolecular diagnostics for Chagas disease: up to date and novel methodologies-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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