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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Huetteroth, Wolf | - |
dc.creator | Perisse, Emmanuel | - |
dc.creator | Lin, Suewei | - |
dc.creator | Klappenbach, Martín | - |
dc.creator | Burke, Christopher | - |
dc.creator | Waddell, Scott | - |
dc.date | 2018-03-08T20:28:19Z | - |
dc.date | 2018-03-08T20:28:19Z | - |
dc.date | 2015-03 | - |
dc.date | 2018-03-02T14:18:25Z | - |
dc.date.accessioned | 2019-04-29T15:49:37Z | - |
dc.date.available | 2019-04-29T15:49:37Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier | Huetteroth, Wolf; Perisse, Emmanuel; Lin, Suewei; Klappenbach, Martín; Burke, Christopher; et al.; Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila; Cell Press; Current Biology; 25; 6; 3-2015; 751-758 | - |
dc.identifier | 0960-9822 | - |
dc.identifier | http://hdl.handle.net/11336/38320 | - |
dc.identifier | CONICET Digital | - |
dc.identifier | CONICET | - |
dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303080 | - |
dc.description | Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β′2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population. | - |
dc.description | Fil: Huetteroth, Wolf. University of Oxford; Reino Unido. University of Konstanz; Alemania | - |
dc.description | Fil: Perisse, Emmanuel. University of Oxford; Reino Unido | - |
dc.description | Fil: Lin, Suewei. University of Oxford; Reino Unido | - |
dc.description | Fil: Klappenbach, Martín. University of Oxford; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina | - |
dc.description | Fil: Burke, Christopher. University of Oxford; Reino Unido | - |
dc.description | Fil: Waddell, Scott. University of Oxford; Reino Unido | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.language | eng | - |
dc.publisher | Cell Press | - |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cub.2015.01.036 | - |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982215000688 | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
dc.source | reponame:CONICET Digital (CONICET) | - |
dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
dc.source | instacron:CONICET | - |
dc.subject | Dopamine | - |
dc.subject | Reward | - |
dc.subject | Drosophila | - |
dc.subject | Otras Ciencias Biológicas | - |
dc.subject | Ciencias Biológicas | - |
dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
dc.title | Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.type | info:ar-repo/semantics/articulo | - |
Aparece en las colecciones: | CONICET |
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