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dc.creatorCittadini, María Cecilia-
dc.creatorGarcía Estévez, Ignacio-
dc.creatorEscribano Bailón, M. Teresa-
dc.creatorRivas Gonzalo, Julián C.-
dc.creatorValentich, Mirta Ana-
dc.creatorRepossi Marquez, Pablo Gaston-
dc.creatorSoria, Elio Andres-
dc.date2018-11-07T18:36:12Z-
dc.date2018-11-07T18:36:12Z-
dc.date2018-02-21-
dc.date2018-10-22T18:58:37Z-
dc.date.accessioned2019-04-29T15:49:42Z-
dc.date.available2019-04-29T15:49:42Z-
dc.date.issued2018-02-21-
dc.identifierCittadini, María Cecilia; García Estévez, Ignacio; Escribano Bailón, M. Teresa; Rivas Gonzalo, Julián C.; Valentich, Mirta Ana; et al.; Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds; Lawrence Erlbaum Assoc Inc-taylor & Francis; Nutrition And Cancer; 70; 2; 21-2-2018; 267-277-
dc.identifier0163-5581-
dc.identifierhttp://hdl.handle.net/11336/63908-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303114-
dc.descriptionDietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune response. The compounds were extracted from Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas and identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) were tested on human T98-G and rat C6 glioma lines. Cellular viability (by the resazurin assay), fatty acid profile (by gas chromatography) and pro-inflammatory interleukin-6 release (IL-6 by ELISA) were determined. Data were analyzed by partial least-square regression to discriminate bioactive compounds. Twenty-one compounds were determined in LG, mainly iridoids, which were linked to ω-3 and ω-6 polyunsaturated fatty acids, but not to IL-6 release. Thirty-one compounds were found in AQB, mostly hydroxybenzoic derivatives, which were positively related to IL-6 release. Twenty-three compounds were identified in IP, including caffeoylquinic derivatives and mainly chlorogenic acid. They increased the ω-7 palmitoleic fatty acid, which was related to IL-6 decrease. These results enhances phytochemical knowledge of widely available plants, and suggest the lipid-related anti-inflammatory activity of IP phenolic compounds, which give nutritional relevance to the tea.-
dc.descriptionFil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Ministerio de Salud; Argentina-
dc.descriptionFil: García Estévez, Ignacio. Universidad de Salamanca; España-
dc.descriptionFil: Escribano Bailón, M. Teresa. Universidad de Salamanca; España-
dc.descriptionFil: Rivas Gonzalo, Julián C.. Universidad de Salamanca; España-
dc.descriptionFil: Valentich, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina-
dc.descriptionFil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina-
dc.descriptionFil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherLawrence Erlbaum Assoc Inc-taylor & Francis-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/01635581.2018.1412484-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01635581.2018.1412484-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectFatty Acids-
dc.subjectInterleukin-6-
dc.subjectGlioma Cells-
dc.subjectIlex paraguariensis-
dc.subjectPhenolic Compounds-
dc.subjectAspidosperma quebracho-blanco-
dc.subjectLantana grisebachii-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectMedicina Critica y de Emergencia-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectSalud Ocupacional-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleModulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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