Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Zeida Camacho, Ari Fernando | - |
| dc.creator | Machado, Matías Rodrigo | - |
| dc.creator | Dans, Pablo Daniel | - |
| dc.creator | Pantano, Sergio | - |
| dc.date | 2019-01-09T18:53:45Z | - |
| dc.date | 2019-01-09T18:53:45Z | - |
| dc.date | 2012-08 | - |
| dc.date | 2019-01-02T19:09:48Z | - |
| dc.date.accessioned | 2019-04-29T15:49:56Z | - |
| dc.date.available | 2019-04-29T15:49:56Z | - |
| dc.date.issued | 2012-08 | - |
| dc.identifier | Zeida Camacho, Ari Fernando; Machado, Matías Rodrigo; Dans, Pablo Daniel; Pantano, Sergio; Breathing, bubbling, and bending: DNA flexibility from multimicrosecond simulations; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 86; 2; 8-2012; 21903-21910 | - |
| dc.identifier | 1539-3755 | - |
| dc.identifier | http://hdl.handle.net/11336/67809 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303214 | - |
| dc.description | Bending of the seemingly stiff DNA double helix is a fundamental physical process for any living organism. Specialized proteins recognize DNA inducing and stabilizing sharp curvatures of the double helix. However, experimental evidence suggests a high protein-independent flexibility of DNA. On the basis of coarse-grained simulations, we propose that DNA experiences thermally induced kinks associated with the spontaneous formation of internal bubbles. Comparison of the protein-induced DNA curvature calculated from the Protein Data Bank with that sampled by our simulations suggests that thermally induced distortions can account for ∼80% of the DNA curvature present in experimentally solved structures. © 2012 American Physical Society. | - |
| dc.description | Fil: Zeida Camacho, Ari Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.description | Fil: Machado, Matías Rodrigo. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.description | Fil: Dans, Pablo Daniel. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.description | Fil: Pantano, Sergio. Instituto Pasteur de Montevideo; Uruguay | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Physical Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1103/PhysRevE.86.021903 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/pre/abstract/10.1103/PhysRevE.86.021903 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | DNA dynamics | - |
| dc.subject | Flexibility | - |
| dc.subject | Breathing | - |
| dc.subject | DNA recognition | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Breathing, bubbling, and bending: DNA flexibility from multimicrosecond simulations | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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