Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Ernst, Glenda | - |
| dc.creator | Jancic, Carolina Cristina | - |
| dc.creator | Auteri, Santiago | - |
| dc.creator | Rodriguez Moncalvo, Juan | - |
| dc.creator | Galíndez, Fernando | - |
| dc.creator | Grynblat, Pedro | - |
| dc.creator | Hajos, Silvia Elvira | - |
| dc.date | 2017-11-30T22:08:18Z | - |
| dc.date | 2017-11-30T22:08:18Z | - |
| dc.date | 2014-05 | - |
| dc.date | 2017-10-09T16:40:53Z | - |
| dc.date.accessioned | 2019-04-29T15:49:57Z | - |
| dc.date.available | 2019-04-29T15:49:57Z | - |
| dc.date.issued | 2014-05 | - |
| dc.identifier | Ernst, Glenda; Jancic, Carolina Cristina; Auteri, Santiago; Rodriguez Moncalvo, Juan; Galíndez, Fernando; et al.; Increased levels of hyaluronic acid in bronchoalveolar lavage from patients with interstitial lung diseases, relationship with lung function and inflammatory cells recruitment; Scientific Research Publishing; Modern Research in Inflammation; 3; 2; 5-2014; 27-36 | - |
| dc.identifier | 2169-9682 | - |
| dc.identifier | http://hdl.handle.net/11336/29413 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303224 | - |
| dc.description | Purpose: Interstitial Lung Diseases (ILD) are characterized by inflammation and fibrosis. It described the role of hyaluronic acid (HA) as an immune-regulator. It is not known if HA contributes to the recruitment of inflammatory cells associated with ILD. If this hypothesis was correct, then concentrations of HA in bronchoalveolar lavage (BAL) should correlate with the severity of ILD. Methods: We collected BAL from 22 ILD patients and 15 control subjects. We determined HA and cytokine levels by ELISA. In vitro chemotaxis assays were performed by using a transwell system. Results: We found that ILD patients showed a significant increase in HA, IL-6 levels and the amount of cells in BAL compared to control subjects. We detected a significant positive correlation between HA and IL-6 levels (r = 0.53 and p < 0.001) and an inverse relationship between HA levels and diffusion capacity (r = -0.59, p < 0.01). In vitro, HA induced migration of macrophages and monocytes through a CD44-dependent process. BAL from patients with ILD stimulated macro-phage migration and this was abrogated by hyaluronidase. Conclusions: Our results support the hypothesis that HA contributes to the recruitment of monocytes towards the alveolar space, leading to exacerbation of lung inflammation in ILD patients. | - |
| dc.description | Fil: Ernst, Glenda. Ciudad Autónoma de Buenos Aires. Hospital María Ferrer; Argentina | - |
| dc.description | Fil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Auteri, Santiago. Ciudad Autónoma de Buenos Aires. Hospital María Ferrer; Argentina | - |
| dc.description | Fil: Rodriguez Moncalvo, Juan. Ciudad Autónoma de Buenos Aires. Hospital María Ferrer; Argentina | - |
| dc.description | Fil: Galíndez, Fernando. Ciudad Autónoma de Buenos Aires. Hospital María Ferrer; Argentina | - |
| dc.description | Fil: Grynblat, Pedro. Ciudad Autónoma de Buenos Aires. Hospital María Ferrer; Argentina | - |
| dc.description | Fil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Scientific Research Publishing | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/mri.2014.32004 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.scirp.org/journal/PaperInformation.aspx?PaperID=45076 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | HYALURONIC ACID | - |
| dc.subject | BRONCHOALVEOLAR LAVAGE | - |
| dc.subject | INTERSTITAL LUNG DESEASES | - |
| dc.subject | INFLAMMATORY CELLS | - |
| dc.subject | Medicina Critica y de Emergencia | - |
| dc.subject | Medicina Clínica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Increased levels of hyaluronic acid in bronchoalveolar lavage from patients with interstitial lung diseases, relationship with lung function and inflammatory cells recruitment | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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