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dc.creatorFustero, Santos-
dc.creatorRoman, Raquel-
dc.creatorSanz Cervera, Juan F.-
dc.creatorSimon Fuentes, Antonio-
dc.creatorCuñat, Ana-
dc.creatorVillanova, Salvador-
dc.creatorMurguia, Marcelo Cesar-
dc.date2017-07-14T14:19:13Z-
dc.date2017-07-14T14:19:13Z-
dc.date2008-12-
dc.date2017-07-10T13:10:11Z-
dc.date.accessioned2019-04-29T15:50:13Z-
dc.date.available2019-04-29T15:50:13Z-
dc.date.issued2008-12-
dc.identifierFustero, Santos; Roman, Raquel; Sanz Cervera, Juan F.; Simon Fuentes, Antonio; Cuñat, Ana; et al.; Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs; American Chemical Society; Journal of Organic Chemistry; 73; 9; 12-2008; 3523-3529-
dc.identifier0022-3263-
dc.identifierhttp://hdl.handle.net/11336/20497-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303331-
dc.descriptionThe preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to the formation of regioisomeric mixtures of N-methylpyrazoles, which sometimes are difficult to separate. We have determined that the use of fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation, and we have used this modification in a straightforward synthesis of fluorinated analogs of Tebufenpyrad with acaricide activity.-
dc.descriptionFil: Fustero, Santos. Universidad de Valencia; España-
dc.descriptionFil: Roman, Raquel. Universidad de Valencia; España-
dc.descriptionFil: Sanz Cervera, Juan F.. Universidad de Valencia; España. Centro de Investigaciones Principe Felipe; España-
dc.descriptionFil: Simon Fuentes, Antonio. Universidad de Valencia; España-
dc.descriptionFil: Cuñat, Ana. Universidad de Valencia; España-
dc.descriptionFil: Villanova, Salvador. Universidad de Valencia; España-
dc.descriptionFil: Murguia, Marcelo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherAmerican Chemical Society-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/jo800251g-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/jo800251g-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectPYRAZOL-
dc.subjectFLUORINATED PYRAZOL-
dc.subjectFLUOROUS-
dc.subjectTEBUFENPYRAD-
dc.subjectQuímica Orgánica-
dc.subjectCiencias Químicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleImproved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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