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dc.creatorD’Souza, Roy N.-
dc.creatorAzevedo, Ana M.-
dc.creatorAires Barros, M. Raquel-
dc.creatorKrajnc, Nika Lendero-
dc.creatorKramberger, Petra-
dc.creatorCarbajal, Maria Laura-
dc.creatorGrasselli, Mariano-
dc.creatorMeyer, Ronald-
dc.creatorFernandez Lahore, Marcelo-
dc.date2017-09-07T14:50:44Z-
dc.date2017-09-07T14:50:44Z-
dc.date2013-01-
dc.date2017-08-04T14:00:49Z-
dc.date.accessioned2019-04-29T15:50:16Z-
dc.date.available2019-04-29T15:50:16Z-
dc.date.issued2013-01-
dc.identifierD’Souza, Roy N.; Azevedo, Ana M.; Aires Barros, M. Raquel; Krajnc, Nika Lendero; Kramberger, Petra; et al.; Emerging technologies for the integration and intensification of downstream bioprocesses; Future Science Ltd.; Pharmaceutical Bioprocessing; 1; 5; 1-2013; 423-440-
dc.identifier2048-9145-
dc.identifierhttp://hdl.handle.net/11336/23762-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303353-
dc.descriptionDownstream processing is currently the major bottleneck for bioproduct generation. In contrast to the advances in fermentation processes, the tools used for downstream processes have struggled to keep pace in the last 20 years. Purification bottlenecks are quite serious, as these processes can account for up to 80% of the total production cost. Coupled with the emergence of new classes of bioproducts, for example, virus-like particles or plasmidic DNA, this has created a great need for superior alternatives. In this review, improved downstream technologies, including aqueous two-phase systems, expanded bed adsorption chromatography, convective flow systems, and fibre-based adsorbent systems, have been discussed. These adaptive methods are more suited to the burgeoning downstream processing needs of the future, enabling the cost-efficient production of new classes biomaterials with a high degree of purity, and thereby hold the promise to become indispensable tools in the pharmaceutical and food industries.-
dc.descriptionFil: D’Souza, Roy N.. Universitat Bremen; Alemania-
dc.descriptionFil: Azevedo, Ana M.. Universidad de Lisboa; Portugal-
dc.descriptionFil: Aires Barros, M. Raquel. Universidad de Lisboa; Portugal-
dc.descriptionFil: Krajnc, Nika Lendero. BIA Separations; Eslovenia-
dc.descriptionFil: Kramberger, Petra. BIA Separations; Eslovenia-
dc.descriptionFil: Carbajal, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina-
dc.descriptionFil: Grasselli, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina-
dc.descriptionFil: Meyer, Ronald. Universitat Bremen; Alemania-
dc.descriptionFil: Fernandez Lahore, Marcelo. Universitat Bremen; Alemania-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherFuture Science Ltd.-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.openaccessjournals.com/abstract/emerging-technologies-for-the-integration-and-intensification-of-downstream-bioprocesses-8126.html-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectMonoclonal antibodies-
dc.subjectpDNA-
dc.subjectVirus-like particle-
dc.subjectAqueous two-phase separation-
dc.subjectExpanded bed adsorption chromatography-
dc.subjectMonolith-
dc.subjectBioprocesamiento Tecnológico, Biocatálisis, Fermentación-
dc.subjectBiotecnología Industrial-
dc.subjectINGENIERÍAS Y TECNOLOGÍAS-
dc.titleEmerging technologies for the integration and intensification of downstream bioprocesses-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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