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dc.creatorFozzatti, Laura-
dc.creatorPark, Jeong Won-
dc.creatorLi, Zhao-
dc.creatorWillingham, Mark C.-
dc.creatorCheng, Sheue-yann-
dc.date2015-05-27T17:34:21Z-
dc.date2015-05-27T17:34:21Z-
dc.date2013-06-26-
dc.date2016-03-30 10:35:44.97925-03-
dc.date.accessioned2019-04-29T15:50:18Z-
dc.date.available2019-04-29T15:50:18Z-
dc.date.issued2013-06-26-
dc.identifierFozzatti, Laura; Park, Jeong Won; Li, Zhao ; Willingham, Mark C.; Cheng, Sheue-yann; Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer; PUBLIC LIBRARY SCIENCE; PLOS ONE; 8; 26-6-2013; 1-10;-
dc.identifier1932-6203-
dc.identifierhttp://hdl.handle.net/11336/582-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303361-
dc.descriptionStudies have suggested that the nuclear receptor corepressor 1 (NCOR1) could play an important role in human cancers. However, the detailed molecular mechanisms by which it functions in vivo to affect cancer progression are not clear. The present study elucidated the in vivo actions of NCOR1 in carcinogenesis using a mouse model (ThrbPV/PV mice) that spontaneously develops thyroid cancer. ThrbPV/PV mice harbor a dominantly negative thyroid hormone receptor b (TRb) mutant (denoted as PV). We adopted the loss-of-the function approach by crossing ThrbPV mice with mice that globally express an NCOR1 mutant protein (NCOR1DID) in which the receptor interaction domains have been modified so that it cannot interact with the TRb, or PV, in mice. Remarkably, expression of NCOR1DID protein reduced thyroid tumor growth, markedly delayed tumor progression, and prolonged survival of ThrbPV/PVNcor1DID/DID mice. Tumor cell proliferation was inhibited by increased expression of cyclin-dependent kinase inhibitor 1 (p21waf1/cip1; Cdkn1A), and apoptosis was activated by elevated expression of pro-apoptotic BCL-Associated X (Bax). Further analyses showed that p53 was recruited to the p53- binding site on the proximal promoter of the Cdkn1A and the Bax gene as a co-repressor complex with PV/NCOR1/histone deacetylas-3 (HDAC-3), leading to repression of the Cdkn1A as well as the Bax gene in thyroids of ThrbPV/PV mice. In thyroids of ThrbPV/PVNcor1DID/DID mice, the p53/PV complex could not recruit NCOR1DID and HDAC-3, leading to de-repression of both genes to inhibit cancer progression. The present studies provided direct evidence in vivo that NCOR1 could function as an oncogene via transcription regulation in a mouse model of thyroid cancer.-
dc.descriptionFil: Fozzatti, Laura. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra;-
dc.descriptionFil: Park, Jeong Won.-
dc.descriptionFil: Li, Zhao.-
dc.descriptionFil: Willingham, Mark C..-
dc.descriptionFil: Cheng, Sheue-yann.-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0067954-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectNUCLEAR RECEPTOR COREPRESSORS-
dc.subjectTHYROID CARCINOGENESIS-
dc.subjectp53-
dc.subjectMOUSE MODEL-
dc.subjectCiencias Médicas y de la Salud-
dc.subjectMedicina Básica-
dc.subjectBioquímica y Biología Molecular (ídem 1.6.3)-
dc.titleOncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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