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Campo DC Valor Lengua/Idioma
dc.creatorCourreges, Maria Cecilia-
dc.creatorBurzyn, Dalia-
dc.creatorNepomnaschy, Irene-
dc.creatorPiazzon, Margarita Isabel-
dc.creatorRoss, Susan R.-
dc.date2018-08-14T18:17:22Z-
dc.date2018-08-14T18:17:22Z-
dc.date2007-04-
dc.date2018-08-13T18:47:07Z-
dc.date.accessioned2019-04-29T15:50:25Z-
dc.date.available2019-04-29T15:50:25Z-
dc.date.issued2007-04-
dc.identifierCourreges, Maria Cecilia; Burzyn, Dalia; Nepomnaschy, Irene; Piazzon, Margarita Isabel; Ross, Susan R.; Critical role of dendritic cells in mouse mammary tumor virus in vivo infection; American Society for Microbiology; Journal of Virology; 81; 8; 4-2007; 3769-3777-
dc.identifier0022-538X-
dc.identifierhttp://hdl.handle.net/11336/55444-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303415-
dc.descriptionMouse mammary tumor virus (MMTV) is a milk-transmitted betaretrovirus that causes mammary tumors in mice. Although mammary epithelial cells are the ultimate targets of MMTV, the virus utilizes components of the host immune system to establish infection. Previous studies indicated that dendritic cells play a role in MMTV infection. Here we show that dendritic cells are the first cells to be infected by MMTV in vivo and that they are capable of producing infectious virus that can be transmitted to other cell types. Moreover, upon contact with the virus, dendritic cells became more mature and migrated in response to the chemokine macrophage inflammatory protein 3β. Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo. Copyright © 2007, American Society for Microbiology. All Rights Reserved.-
dc.descriptionFil: Courreges, Maria Cecilia. University of Pennsylvania; Estados Unidos-
dc.descriptionFil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: Ross, Susan R.. University of Pennsylvania; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherAmerican Society for Microbiology-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1128/JVI.02728-06-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://jvi.asm.org/content/81/8/3769-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectMMTV-
dc.subjectDENDRITIC CELLS-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleCritical role of dendritic cells in mouse mammary tumor virus in vivo infection-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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