Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Silva, Marcia S. | - |
| dc.creator | Lúcio Oliveira, Fabiana | - |
| dc.creator | Mecawi, Andre Souza | - |
| dc.creator | Almeida, Lucas F. | - |
| dc.creator | Ruginsk, Silvia G. | - |
| dc.creator | Greenwood, Michael P. | - |
| dc.creator | Greenwood, Mingkwan | - |
| dc.creator | Vivas, Laura Marta | - |
| dc.creator | Elias, Lucila L. K. | - |
| dc.creator | Murphy, David | - |
| dc.creator | Antunes Rodrigues, José | - |
| dc.date | 2018-11-09T13:20:10Z | - |
| dc.date | 2018-11-09T13:20:10Z | - |
| dc.date | 2017-03-29 | - |
| dc.date | 2018-10-22T15:50:37Z | - |
| dc.date.accessioned | 2019-04-29T15:50:44Z | - |
| dc.date.available | 2019-04-29T15:50:44Z | - |
| dc.date.issued | 2017-03-29 | - |
| dc.identifier | Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; et al.; Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring; American Physiological Society; Physiological Reports; 5; 6; 29-3-2017; 1-13 | - |
| dc.identifier | 2051-817X | - |
| dc.identifier | http://hdl.handle.net/11336/64054 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303551 | - |
| dc.description | Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life. | - |
| dc.description | Fil: Silva, Marcia S.. Universidade de Sao Paulo; Brasil | - |
| dc.description | Fil: Lúcio Oliveira, Fabiana. Universidade de Sao Paulo; Brasil | - |
| dc.description | Fil: Mecawi, Andre Souza. University of Malaya; Malasia | - |
| dc.description | Fil: Almeida, Lucas F.. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil | - |
| dc.description | Fil: Ruginsk, Silvia G.. Federal University of Alfenas; Brasil | - |
| dc.description | Fil: Greenwood, Michael P.. University of Bristol; Reino Unido | - |
| dc.description | Fil: Greenwood, Mingkwan. University of Bristol; Reino Unido | - |
| dc.description | Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina | - |
| dc.description | Fil: Elias, Lucila L. K.. Universidade de Sao Paulo; Brasil | - |
| dc.description | Fil: Murphy, David. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil | - |
| dc.description | Fil: Antunes Rodrigues, José. Universidade de Sao Paulo; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Physiological Society | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.14814/phy2.13210 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13210 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | PERINATAL PROGRAMMING | - |
| dc.subject | SODIUM PREFERENCE RATIO | - |
| dc.subject | THIRST | - |
| dc.subject | VASOPRESSIN | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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