Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Leal, P. C. | - |
| dc.creator | Mascarello, A. | - |
| dc.creator | Derita, Marcos Gabriel | - |
| dc.creator | Zuljan, Federico Alberto | - |
| dc.creator | Nunes, R. J. | - |
| dc.creator | Zacchino, Susana Alicia Stella | - |
| dc.creator | Yunes, R. A. | - |
| dc.date | 2018-08-07T19:01:00Z | - |
| dc.date | 2018-08-07T19:01:00Z | - |
| dc.date | 2009-03 | - |
| dc.date | 2018-08-06T14:11:19Z | - |
| dc.date.accessioned | 2019-04-29T15:50:50Z | - |
| dc.date.available | 2019-04-29T15:50:50Z | - |
| dc.date.issued | 2009-03 | - |
| dc.identifier | Leal, P. C.; Mascarello, A.; Derita, Marcos Gabriel; Zuljan, Federico Alberto; Nunes, R. J.; et al.; Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 19; 6; 3-2009; 1793-1796 | - |
| dc.identifier | 0960-894X | - |
| dc.identifier | http://hdl.handle.net/11336/54465 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303590 | - |
| dc.description | The antifungal activity of a complete series of 15 n-alkyl gallates and six analogues acting against a representative panel of opportunistic pathogenic fungi was studied in order to analyze their role in: the importance of the fungi tested, the importance of the hydroxyls, the influence of the chain length and the hydrophobicity of the compounds. It was demonstrated that dermatophytes were the most susceptible species and that hydroxyls appear to be necessary but not sufficient for the activity. When the log P of each gallate was calculated and related to the different values of MIC against Microsporum gypseum it was observed that hexyl, heptyl, octyl and nonyl gallates exhibit a significant positive deviation from the curve corresponding to a polynomial equation obtained for the other gallates. This suggests that these compounds have a further mode of action besides their hydrophobicity, possibly the inhibition of some enzyme involved in ergosterol biosynthesis. © 2009 Elsevier Ltd. All rights reserved. | - |
| dc.description | Fil: Leal, P. C.. Universidade Federal de Santa Catarina; Brasil | - |
| dc.description | Fil: Mascarello, A.. Universidade Federal de Santa Catarina; Brasil | - |
| dc.description | Fil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina | - |
| dc.description | Fil: Zuljan, Federico Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina | - |
| dc.description | Fil: Nunes, R. J.. Universidade Federal de Santa Catarina; Brasil | - |
| dc.description | Fil: Zacchino, Susana Alicia Stella. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina | - |
| dc.description | Fil: Yunes, R. A.. Universidade Federal de Santa Catarina; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Pergamon-Elsevier Science Ltd | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.bmcl.2009.01.061 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X09000845 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ANTIFUNGAL ACTIVITY | - |
| dc.subject | GALLATES | - |
| dc.subject | LIPOPHILICITY | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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