Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Inda, María Carolina | - |
| dc.creator | Armando, Natalia Giannina | - |
| dc.creator | Dos Santos Claro, Paula Ayelen | - |
| dc.creator | Silberstein Cuña, Susana Iris | - |
| dc.date | 2018-06-22T20:26:57Z | - |
| dc.date | 2018-06-22T20:26:57Z | - |
| dc.date | 2017-07-14 | - |
| dc.date | 2018-06-19T15:59:36Z | - |
| dc.date.accessioned | 2019-04-29T15:50:59Z | - |
| dc.date.available | 2019-04-29T15:50:59Z | - |
| dc.date.issued | 2017-07-14 | - |
| dc.identifier | Inda, María Carolina; Armando, Natalia Giannina; Dos Santos Claro, Paula Ayelen; Silberstein Cuña, Susana Iris; Endocrinology and the brain: Corticotropin-Releasing Hormone signaling; BioScientifica; Endocrine Connections; 6; 6; 14-7-2017; 99-120 | - |
| dc.identifier | 2049-3614 | - |
| dc.identifier | http://hdl.handle.net/11336/49780 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303654 | - |
| dc.description | Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G protein-coupled receptors (GPCRs) CRHR1 and CRHR2, and summarizes recent findings that challenge the classical view of GPCR signaling, and impact on our understanding of CRHRs function. Special emphasis is placed on recent studies of CRH signaling that revealed new mechanistic aspects of cAMP generation and ERK1/2 activation in physiologically relevant contexts of the neurohormone action. In addition, we present an overview of the pathophysiological role of the CRH system, which highlights the need for a precise definition of CRHRs signaling at molecular level to identify novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. | - |
| dc.description | Fil: Inda, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina | - |
| dc.description | Fil: Armando, Natalia Giannina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina | - |
| dc.description | Fil: Dos Santos Claro, Paula Ayelen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina | - |
| dc.description | Fil: Silberstein Cuña, Susana Iris. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | BioScientifica | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/EC-17-0111 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.endocrineconnections.com/content/6/6/R99 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CRH SYSTEM PATHOPHYSIOLOGY | - |
| dc.subject | CYCLIC AMP | - |
| dc.subject | ERK1/2 | - |
| dc.subject | CRH RECEPTOR SIGNALING | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Endocrinology and the brain: Corticotropin-Releasing Hormone signaling | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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