Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Lombardi, Gabriela | - |
| dc.creator | Burzyn, Dalia | - |
| dc.creator | Mundiñano, Juliana | - |
| dc.creator | Berguer, Paula Mercedes | - |
| dc.creator | Costa, Hector Luis | - |
| dc.creator | Goldman, Alejandra | - |
| dc.creator | Piazzon, Margarita Isabel | - |
| dc.creator | Nepomnaschy, Irene | - |
| dc.date | 2018-08-14T00:39:11Z | - |
| dc.date | 2018-08-14T00:39:11Z | - |
| dc.date | 2006-05 | - |
| dc.date | 2018-08-13T18:44:52Z | - |
| dc.date.accessioned | 2019-04-29T15:51:02Z | - |
| dc.date.available | 2019-04-29T15:51:02Z | - |
| dc.date.issued | 2006-05 | - |
| dc.identifier | Lombardi, Gabriela; Burzyn, Dalia; Mundiñano, Juliana; Berguer, Paula Mercedes; Costa, Hector Luis; et al.; Response to Comment on "Cathepsin-L Influences the Expression of Extracellular Matrix in Lymphoid Organs and Plays a Role in the Regulation of Thymic Output and of Peripheral T Cell Number"; American Association of Immunologists; Journal of Immunology; 176; 9; 5-2006; 5135-5136 | - |
| dc.identifier | 0022-1767 | - |
| dc.identifier | http://hdl.handle.net/11336/55312 | - |
| dc.identifier | 16621972 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303672 | - |
| dc.description | In our article published in The Journal of Immunology in June 1, 2005 (1), we reported that lymph nodes from nackt mice (CTSLnkt/CTSLnkt) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked increase in the number of CD8+ T lymphocytes. Correlatively, extracellular matrix (ECM) components were found to be increased. Contrarily, in nackt thymus, laminin, fibronectin, and collagen I and IV are markedly decreased, with an augmented output of CD8+ cells. We also reported that a mutated form of cathepsin L can be detected in different organs in nackt mice. These results demonstrate that the nackt mutation in the Ctsl gene influences the levels of ECM components in lymphoid organs, the thymic output, and the number of T cells in the periphery, thus broadly affecting the immune system. | - |
| dc.description | Fil: Lombardi, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Mundiñano, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Berguer, Paula Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Costa, Hector Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Goldman, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Association of Immunologists | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=16621972 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4049/jimmunol.176.9.5135 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CATHEPSINS | - |
| dc.subject | LYMPHOID | - |
| dc.subject | GENE EXPRESSION | - |
| dc.subject | CYSTEINE ENDOPEPTIDASES | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Response to Comment on "Cathepsin-L Influences the Expression of Extracellular Matrix in Lymphoid Organs and Plays a Role in the Regulation of Thymic Output and of Peripheral T Cell Number" | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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