Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Kamper, Peter | - |
| dc.creator | Lugvigsen, Maja | - |
| dc.creator | Bendix, Knud | - |
| dc.creator | Hamilton Dutoit, Stephen | - |
| dc.creator | Rabinovich, Gabriel Adrian | - |
| dc.creator | Boe Møller, Michael | - |
| dc.creator | Nyengaard, Jens | - |
| dc.creator | Honoré, Bent | - |
| dc.creator | d'Amore, Franceso | - |
| dc.date | 2017-01-02T14:51:24Z | - |
| dc.date | 2017-01-02T14:51:24Z | - |
| dc.date | 2011-06 | - |
| dc.date | 2016-12-30T13:43:20Z | - |
| dc.date.accessioned | 2019-04-29T15:51:04Z | - |
| dc.date.available | 2019-04-29T15:51:04Z | - |
| dc.date.issued | 2011-06 | - |
| dc.identifier | Kamper, Peter; Lugvigsen, Maja; Bendix, Knud; Hamilton Dutoit, Stephen; Rabinovich, Gabriel Adrian; et al.; Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma; American Society Of Hematology; Blood, The Journal Of The American Society Of Hematology - Print; 117; 24; 6-2011; 6638-6649 | - |
| dc.identifier | 0006-4971 | - |
| dc.identifier | 1528-0020 | - |
| dc.identifier | http://hdl.handle.net/11336/10664 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303686 | - |
| dc.description | Considerable effort has been spent identifying prognostic biomarkers in classic Hodgkin lymphoma (cHL). The aim of our study was to search for possible prognostic parameters in advanced-stage cHL using a proteomics-based strategy. A total of 14 cHL pretreatment tissue samples from younger, advanced-stage patients were included. Patients were grouped according to treatment response. Proteins that were differentially expressed between the groups were analyzed using 2D-PAGE and identified by liquid chromatography mass spectrometry. Selected proteins were validated using Western blot analysis. One of the differentially expressed proteins, the carbohydrate-binding protein galectin-1 (Gal-1), was further analyzed using immunohistochemistry HC and its expression was correlated with clinicopathologic and outcome parameters in 143 advanced-stage cHL cases. At the univariate level, high Gal-1 expression in the tumor microenvironment was correlated with poor event-free survival (P = .02). Among younger (≤ 61 years) patients, high Gal-1 was correlated with poorer overall and event-free survival (both P = .007). In this patient group and at the multivariate level, high Gal-1 expression retained a significant predictive impact on event-free survival. Therefore, in addition to its functional role in cHL-induced immunosuppression, Gal-1 is also associated with an adverse clinical outcome in this disease. | - |
| dc.description | Fil: Kamper, Peter. Aarhus University Hospital. Department of Hematology; Dinamarca | - |
| dc.description | Fil: Lugvigsen, Maja. University Aarhus; Dinamarca | - |
| dc.description | Fil: Bendix, Knud. Aarhus University Hospital. Institute of Pathology; Dinamarca | - |
| dc.description | Fil: Hamilton Dutoit, Stephen. Aarhus University Hospital. Institute of Pathology; Dinamarca | - |
| dc.description | Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Boe Møller, Michael. Odense University Hospital. Department of Pathology; Dinamarca | - |
| dc.description | Fil: Nyengaard, Jens. Aarhus University Hospital. Center for Stochastic Geometry and Advanced Bioimaging. Stereology & Electron Microscopy Laboratory; Dinamarca | - |
| dc.description | Fil: Honoré, Bent. University Aarhus; Dinamarca | - |
| dc.description | Fil: d'Amore, Franceso. Aarhus University Hospital. Department of Hematology; Dinamarca | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society Of Hematology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/117/24/6638 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1182/blood-2010-12-327346 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | HODGKIN LYMPHOMA | - |
| dc.subject | BIOMARKER | - |
| dc.subject | GALECTIN-1 | - |
| dc.subject | PROTEOMICS | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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