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dc.creatorLerner, Leticia K.-
dc.creatorFrancisco, Guilherme-
dc.creatorSoltys, Daniela T.-
dc.creatorRocha, Clarissa R.R.-
dc.creatorQuinet, Annabel-
dc.creatorVessoni, Alexandre T.-
dc.creatorCastro, Ligia P.-
dc.creatorDavid, Taynah I.P.-
dc.creatorBustos, Silvina O.-
dc.creatorStrauss, Bryan E.-
dc.creatorGottifredi, Vanesa-
dc.creatorStary, Anne-
dc.creatorSarasin, Alain-
dc.creatorChammas, Roger-
dc.creatorMenck, Carlos F.M.-
dc.date2018-07-18T15:17:38Z-
dc.date2018-07-18T15:17:38Z-
dc.date2017-02-
dc.date2018-07-11T17:39:04Z-
dc.date.accessioned2019-04-29T15:51:09Z-
dc.date.available2019-04-29T15:51:09Z-
dc.date.issued2017-02-
dc.identifierLerner, Leticia K.; Francisco, Guilherme; Soltys, Daniela T.; Rocha, Clarissa R.R.; Quinet, Annabel; et al.; Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells; Oxford University Press; Nucleic Acids Research; 45; 3; 2-2017; 1270-1280-
dc.identifier0305-1048-
dc.identifierhttp://hdl.handle.net/11336/52557-
dc.identifier1362-4962-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303723-
dc.descriptionGenome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53 also plays an important role in preventing cell death after ultraviolet (UV) light exposure. Intriguingly, we show that p53 does so by favoring translesion DNA synthesis by pol eta. In fact, the p53-dependent induction of pol eta in normal and DNA repair-deficient XP-C human cells after UV exposure has a protective effect on cell survival after challenging UV exposures, which was absent in p53- and Pol H-silenced cells. Viability increase was associated with improved elongation of nascent DNA, indicating the protective effect was due to more efficient lesion bypass by pol eta. This protection was observed in cells proficient or deficient in nucleotide excision repair, suggesting that, from a cell survival perspective, proper bypass of DNA damage can be as relevant as removal. These results indicate p53 controls the induction of pol eta in DNA damaged human cells, resulting in improved TLS and enhancing cell tolerance to DNA damage, which parallels SOS responses in bacteria.-
dc.descriptionFil: Lerner, Leticia K.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Francisco, Guilherme. Cancer Institute Of The State Of Sao Paulo; Brasil-
dc.descriptionFil: Soltys, Daniela T.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Rocha, Clarissa R.R.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Quinet, Annabel. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Vessoni, Alexandre T.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Castro, Ligia P.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: David, Taynah I.P.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Bustos, Silvina O.. Cancer Institute Of The State Of Sao Paulo; Brasil-
dc.descriptionFil: Strauss, Bryan E.. Universidade de Sao Paulo; Brasil-
dc.descriptionFil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina-
dc.descriptionFil: Stary, Anne. Centre National de la Recherche Scientifique; Francia-
dc.descriptionFil: Sarasin, Alain. Centre National de la Recherche Scientifique; Francia-
dc.descriptionFil: Chammas, Roger. Cancer Institute Of The State Of São Paulo; Brasil-
dc.descriptionFil: Menck, Carlos F.M.. Universidade de Sao Paulo; Brasil-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherOxford University Press-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/article/45/3/1270/2631187-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/nar/gkw1196-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectp53-
dc.subjectTRANLESION DNA SYNTHESIS-
dc.subjectSOS RESPONSE-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titlePredominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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