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dc.creatorJimenez Balsa, Adrián-
dc.creatorDodero, Veronica Isabel-
dc.creatorMascareñas, José L.-
dc.date2016-06-01T13:32:59Z-
dc.date2016-06-01T13:32:59Z-
dc.date2013-06-
dc.date2016-04-19T20:50:19Z-
dc.date.accessioned2019-04-29T15:51:21Z-
dc.date.available2019-04-29T15:51:21Z-
dc.date.issued2013-06-
dc.identifierJimenez Balsa, Adrián ; Dodero, Veronica Isabel; Mascareñas, José L.; Toward encoding reactivity using double-stranded DNA. Sequencedependent native chemical ligation of DNA binding polyamides; Elsevier; Tetrahedron; 69; 36; 6-2013; 7847-7853-
dc.identifier0040-4020-
dc.identifierhttp://hdl.handle.net/11336/5978-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303815-
dc.descriptionThe coupling reaction between distamycin-related polyamides equipped with cysteine and thioester groups can be accelerated in the presence of double-stranded (ds) oligonucleotides with selected sequences. While the coupling reaction of reactive partners containing three pyrrole units is accelerated by dsDNAs containing ATTTTA or ATGTTA sites, the heterodimeric coupling between a tripyrrole and a polyamide equipped with two pyrroles and one imidazole, is accelerated by the latter DNA, but not by the other containing the A/T rich tract. These differences can be exploited for selecting preferred coupling pairs from a mixture of reactive monomers; therefore the reaction outcome depends on the instructions provided by the dsDNA sequence.-
dc.descriptionFil: Jimenez Balsa, Adrián . Universidad de Santiago de Compostela. Facultad de Quimica. Departamento de Quimica Organica; España-
dc.descriptionFil: Dodero, Veronica Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad de Santiago de Compostela. Departamento de Física Aplicada; España-
dc.descriptionFil: Mascareñas, José L.. Universidad de Santiago de Compostela. Facultad de Quimica. Departamento de Quimica Organica; España-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tet.2013.05.126-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.tet.2013.05.126-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0040402013008946-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectDNA BINDING-
dc.subjectNATIVE CHEMICAL LIGATION-
dc.subjectMOLECULAR RECOGNITION-
dc.subjectPOLYAMIDES-
dc.subjectQuímica Orgánica-
dc.subjectCiencias Químicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleToward encoding reactivity using double-stranded DNA. Sequencedependent native chemical ligation of DNA binding polyamides-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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