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dc.creatorSalomón, Débora Gisele-
dc.creatorFermento, María Eugenia-
dc.creatorGandini, Norberto Ariel-
dc.creatorFerronato, María Julia-
dc.creatorArevalo, Julian-
dc.creatorBlasco, J.-
dc.creatorAndrés, Nancy Carolina-
dc.creatorZenklusen, Jean C.-
dc.creatorCurino, Alejandro Carlos-
dc.creatorFacchinetti, Maria Marta-
dc.date2016-04-22T14:26:46Z-
dc.date2016-04-22T14:26:46Z-
dc.date2014-05-
dc.date2016-05-06 15:52:43.262787-03-
dc.date.accessioned2019-04-29T15:51:33Z-
dc.date.available2019-04-29T15:51:33Z-
dc.date.issued2014-05-
dc.identifierSalomón, Débora Gisele; Fermento, María Eugenia; Gandini, Norberto Ariel; Ferronato, María Julia; Arevalo, Julian; et al.; Vitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme; Springer; Journal Of Neuro-oncology.; 118; 1; 5-2014; 49-60-
dc.identifier0167-594X-
dc.identifierhttp://hdl.handle.net/11336/5331-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303914-
dc.descriptionVitamin D and its analogs have been shown to display anti-proliferative effects in a wide variety of cancer types including glioblastoma multiforme (GBM). These anticancer effects are mediated by its active metabolite, 1α, 25-dihydroxyvitamin D3 (calcitriol) acting mainly through vitamin D receptor (VDR) signaling. In addition to its involvement in calcitriol action, VDR has also been demonstrated to be useful as a prognostic factor for some types of cancer. However, to our knowledge, there are no studies evaluating the expression of VDR protein and its association with outcome in gliomas. Therefore, we investigated VDR expression by using immunohistochemical analysis in human glioma tissue microarrays, and analyzed the association between VDR expression and clinico-pathological parameters. We further investigated the effects of genetic and pharmacologic modulation of VDR on survival and migration of glioma cell lines. Our data demonstrate that VDR is increased in tumor tissues when compared with VDR in non-malignant brains, and that VDR expression is associated with an improved outcome in patients with GBM. We also show that both genetic and pharmacologic modulation of VDR modulates GBM cellular migration and survival and that VDR is necessary for calcitriol-mediated effects on migration. Altogether these results provide some limited evidence supporting a role for VDR in glioma progression.-
dc.descriptionFil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentina-
dc.descriptionFil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentina-
dc.descriptionFil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentina-
dc.descriptionFil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentina-
dc.descriptionFil: Arevalo, Julian. Hospital Municipal General de Agudos Doctor José Penna; Argentina-
dc.descriptionFil: Blasco, J.. Hospital Int. Gral. de Agudos Dr. Jose Penna. Servicio de Patologia; Argentina-
dc.descriptionFil: Andrés, Nancy Carolina. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentina-
dc.descriptionFil: Zenklusen, Jean C.. National Institutes of Health. National Cancer Institute; Estados Unidos-
dc.descriptionFil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentina-
dc.descriptionFil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentina-
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dc.languageeng-
dc.publisherSpringer-
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/24584679-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs11060-014-1416-3-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.​1007/​s11060-014-1416-3-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.​1007/​s11060-014-1416-3-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectVITAMIN D RECEPTOR-
dc.subjectHUMAN GBM-
dc.subjectTISSUE MICROARRAY-
dc.subjectBIOMARKER-
dc.subjectSURVIVAL-
dc.subjectPROGNOSIS-
dc.subjectOncología-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleVitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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