Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Kembro, Jackelyn Melissa | - |
| dc.creator | Aon, Miguel A. | - |
| dc.creator | Winslow, Raimond L. | - |
| dc.creator | O'Rourke, Brian | - |
| dc.creator | Cortassa, Sonia del Carmen | - |
| dc.date | 2017-09-22T17:47:13Z | - |
| dc.date | 2017-09-22T17:47:13Z | - |
| dc.date | 2013-01 | - |
| dc.date | 2017-08-09T14:25:45Z | - |
| dc.date.accessioned | 2019-04-29T15:51:38Z | - |
| dc.date.available | 2019-04-29T15:51:38Z | - |
| dc.date.issued | 2013-01 | - |
| dc.identifier | Kembro, Jackelyn Melissa; Aon, Miguel A.; Winslow, Raimond L.; O'Rourke, Brian; Cortassa, Sonia del Carmen; Integrating mitochondrial energetics, Redox and ROS metabolic networks: a two-compartment model; Elsevier; Biophysical Journal; 104; 2; 1-2013; 332-343 | - |
| dc.identifier | 0006-3495 | - |
| dc.identifier | http://hdl.handle.net/11336/24945 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303952 | - |
| dc.description | To understand the mechanisms involved in the control and regulation of mitochondrial reactive oxygen species (ROS) levels, a two-compartment computational mitochondrial energetic-redox (ME-R) model accounting for energetic, redox, and ROS metabolisms is presented. The ME-R model incorporates four main redox couples (NADH/NAD+, NADPH/NADP+, GSH/GSSG, Trx(SH)2/TrxSS). Scavenging systems—glutathione, thioredoxin, superoxide dismutase, catalase—are distributed in mitochondrial matrix and extra-matrix compartments, and transport between compartments of ROS species (superoxide: O2⋅−, hydrogen peroxide: H2O2), and GSH is also taken into account. Model simulations are compared with experimental data obtained from isolated heart mitochondria. The ME-R model is able to simulate: i), the shape and order of magnitude of H2O2 emission and dose-response kinetics observed after treatment with inhibitors of the GSH or Trx scavenging systems and ii), steady and transient behavior of ΔΨm and NADH after single or repetitive pulses of substrate- or uncoupler-elicited energetic-redox transitions. The dynamics of the redox environment in both compartments is analyzed with the model following substrate addition. The ME-R model represents a useful computational tool for exploring ROS dynamics, the role of compartmentation in the modulation of the redox environment, and how redox regulation participates in the control of mitochondrial function. | - |
| dc.description | Fil: Kembro, Jackelyn Melissa. University Johns Hopkins; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Aon, Miguel A.. University Johns Hopkins; Estados Unidos | - |
| dc.description | Fil: Winslow, Raimond L.. Institute for Computational Medicine; Estados Unidos | - |
| dc.description | Fil: O'Rourke, Brian. University Johns Hopkins; Estados Unidos | - |
| dc.description | Fil: Cortassa, Sonia del Carmen. University Johns Hopkins; Estados Unidos. Institute for Computational Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bpj.2012.11.3808 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006349512050552 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Mitochondria | - |
| dc.subject | Redox environment | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Integrating mitochondrial energetics, Redox and ROS metabolic networks: a two-compartment model | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.