1. RODNA
  2. CONICET
  3. CONICET
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.creatorDasgupta, Indrani-
dc.creatorTanifum, Eric A.-
dc.creatorSrivastava, Mayank-
dc.creatorPhatak, Sharangdhar S.-
dc.creatorCavasotto, Claudio Norberto-
dc.creatorAnaloui, Mostafa-
dc.creatorAnnapragada, Ananth-
dc.date2019-01-29T21:00:08Z-
dc.date2019-01-29T21:00:08Z-
dc.date2012-01-
dc.date2019-01-29T18:09:42Z-
dc.date.accessioned2019-04-29T15:51:39Z-
dc.date.available2019-04-29T15:51:39Z-
dc.date.issued2012-01-
dc.identifierDasgupta, Indrani; Tanifum, Eric A.; Srivastava, Mayank; Phatak, Sharangdhar S.; Cavasotto, Claudio Norberto; et al.; Non inflammatory boronate based glucose-responsive insulin delivery systems; Public Library of Science; Plos One; 7; 1; 1-2012; 1-11; e29585-
dc.identifierhttp://hdl.handle.net/11336/68938-
dc.identifier1932-6203-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303958-
dc.descriptionBoronic acids, known to bind diols, were screened to identify non-inflammatory cross-linkers for the preparation of glucose sensitive and insulin releasing agglomerates of liposomes (Agglomerated Vesicle Technology-AVT). This was done in order to select a suitable replacement for the previously used cross-linker, ConcanavalinA (ConA), a lectin known to have both toxic and inflammatory effects in vivo. Lead-compounds were selected from screens that involved testing for inflammatory potential, cytotoxicity and glucose-binding. These were then conjugated to insulin-encapsulating nanoparticles and agglomerated via sugar-boronate ester linkages to form AVTs. In vitro, the particles demonstrated triggered release of insulin upon exposure to physiologically relevant concentrations of glucose (10 mmoles/L-40 mmoles/L). The agglomerates were also shown to be responsive to multiple spikes in glucose levels over several hours, releasing insulin at a rate defined by the concentration of the glucose trigger.-
dc.descriptionFil: Dasgupta, Indrani. University of Texas; Estados Unidos-
dc.descriptionFil: Tanifum, Eric A.. Baylor College of Medicine; Estados Unidos-
dc.descriptionFil: Srivastava, Mayank. Baylor College of Medicine; Estados Unidos-
dc.descriptionFil: Phatak, Sharangdhar S.. University of Texas; Estados Unidos-
dc.descriptionFil: Cavasotto, Claudio Norberto. University of Texas; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Analoui, Mostafa. Cense Biosciences; Estados Unidos-
dc.descriptionFil: Annapragada, Ananth. Baylor College of Medicine; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherPublic Library of Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0029585-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029585-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectDrug delivery-
dc.subjectInsulin delivery systems-
dc.subjectInflamation-
dc.subjectBoronates-
dc.subjectOtras Ciencias Químicas-
dc.subjectCiencias Químicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleNon inflammatory boronate based glucose-responsive insulin delivery systems-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: CONICET

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem