Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Ibañez, Andres Esteban | - |
| dc.creator | Smaldini, Paola Lorena | - |
| dc.creator | Coria, Lorena | - |
| dc.creator | Delpino, María Victoria | - |
| dc.creator | Pacífico, Lucila G. | - |
| dc.creator | Oliveira, Sergio C. | - |
| dc.creator | Risso, Gabriela Sofía | - |
| dc.creator | Pasquevich, Karina Alejandra | - |
| dc.creator | Fossati, Carlos Alberto | - |
| dc.creator | Giambartolomei, Guillermo Hernan | - |
| dc.creator | Docena, Guillermo H. | - |
| dc.creator | Cassataro, Juliana | - |
| dc.date | 2015-05-19T18:34:38Z | - |
| dc.date | 2015-05-19T18:34:38Z | - |
| dc.date | 2013-07 | - |
| dc.date | 2015-05-15T19:13:43Z | - |
| dc.date.accessioned | 2019-04-29T15:51:42Z | - |
| dc.date.available | 2019-04-29T15:51:42Z | - |
| dc.date.issued | 2013-07 | - |
| dc.identifier | Andrés E. Ibañez; Paola Smaldini; Lorena M. Coria; M Victoria Delpino; Lg Pacifico; Sergio C Oliveira; Gabriela S Risso; Karina A Paskevich; Carlos A Fossati; Guillermo H. Giambartolomei; Guillermo Docena; Juliana Cassataro; Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow’s Milk Proteins.; Public Library Science; Plos One; 2013-7; 1-13; | - |
| dc.identifier | 1932-6203 | - |
| dc.identifier | http://hdl.handle.net/11336/506 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/303979 | - |
| dc.description | The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of UOmp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVAspecific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a<br />mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cow’s Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could be used as a broad Th1 mucosal adjuvant for different Ag formulations. | - |
| dc.description | Fil: Ibañez, Andres Esteban. Universidad de Buenos Aires. Facultad de Medicina. Htal.de Clinicas Gral.san Martin. Laboratorio de Inmunogenetica; | - |
| dc.description | Fil: Smaldini, Paola Lorena. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biologicas. Laboratorio de Invest.del Sistema Inmune; | - |
| dc.description | Fil: Coria, Lorena. Universidad de Buenos Aires. Facultad de Medicina. Htal.de Clinicas Gral.san Martin. Laboratorio de Inmunogenetica; | - |
| dc.description | Fil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Medicina. Htal.de Clinicas Gral.san Martin. Laboratorio de Inmunogenetica; | - |
| dc.description | Fil: Pacifico, Lucila G.. Department of Biochemistry and Immunology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte. Minas Gerais; Brazil; | - |
| dc.description | Fil: Oliveira, Sergio C.. Department of Biochemistry and Immunology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte. Minas Gerais; Brazil; | - |
| dc.description | Fil: Risso, Gabriela Sofía. Universidad de Buenos Aires. Facultad de Medicina. Htal.de Clinicas Gral.san Martin. Laboratorio de Inmunogenetica; | - |
| dc.description | Fil: Pasquevich, Karina Alejandra. Universidad de Buenos Aires. Facultad de Medicina. Htal.de Clinicas Gral.san Martin. Laboratorio de Inmunogenetica; | - |
| dc.description | Fil: Carlos A Fossati. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Est.de la Inmunidad Humoral Prof.r.a.margni; | - |
| dc.description | Fil: Giambartolomei, Guillermo Hernan. Universidad de Buenos Aires. Facultad de Medicina. Htal.de Clinicas Gral.san Martin. Laboratorio de Inmunogenetica; | - |
| dc.description | Fil: Docena, Guillermo H.. Universidad Nacional de la Plata. Facultad de Cs.exactas. Departamento de Cs.biologicas. Laboratorio de Invest.del Sistema Inmune; | - |
| dc.description | Fil: Cassataro, Juliana. Universidad de Buenos Aires. Facultad de Medicina. Htal.de Clinicas Gral.san Martin. Laboratorio de Inmunogenetica; | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Public Library Science | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ADYUVANT | - |
| dc.subject | OMP16 | - |
| dc.subject | BRUCELLA | - |
| dc.subject | VACCINE | - |
| dc.subject | Ciencias Naturales y Exactas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.title | Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow’s Milk Proteins. | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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